Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist within the valve tissue. Given the persistence of myofibrobla...

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Detalles Bibliográficos
Autores principales: Walker, Cierra J., Batan, Dilara, Bishop, Carrie T., Ramirez, Daniel, Aguado, Brian A., Schroeder, Megan E., Crocini, Claudia, Schwisow, Jessica, Moulton, Karen, Macdougall, Laura, Weiss, Robert M., Allen, Mary A., Dowell, Robin, Leinwand, Leslie A., Anseth, Kristi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472021/
https://www.ncbi.nlm.nih.gov/pubmed/36176599
http://dx.doi.org/10.1002/btm2.10394

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