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Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity

BACKGROUND: Immunosuppressive extracellular adenosine is generated by the enzymatic activity of CD73. In preclinical models, antibodies (Abs) targeting different epitopes on CD73 exert anticancer activity through distinct mechanisms such as inhibition of enzymatic activity, engagement of Fc receptor...

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Detalles Bibliográficos
Autores principales:	Gammelgaard, Odd L, Terp, Mikkel G, Renn, Christian, Labrijn, Aran F, Hamaker, Oliver, Nielsen, Aaraby Y, Vever, Henriette, Hansen, Soren WK, Gjerstorff, Morten F, Müller, Christa E, Parren, Paul WHI, Ditzel, Henrik J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472124/ https://www.ncbi.nlm.nih.gov/pubmed/36096528 http://dx.doi.org/10.1136/jitc-2022-004554

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