Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma

BACKGROUND: Merkel cell carcinoma (MCC) often responds to PD-1 pathway blockade, regardless of tumor-viral status (~80% of cases driven by the Merkel cell polyomavirus (MCPyV)). Prior studies have characterized tumor-specific T cell responses to MCPyV, which have typically been CD8, but little is kn...

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Detalles Bibliográficos
Autores principales: Church, Candice, Pulliam, Thomas, Longino, Natalie, Park, Song Y, Smythe, Kimberly S, Makarov, Vladimir, Riaz, Nadeem, Jing, Lichen, Amezquita, Robert, Campbell, Jean S, Gottardo, Raphael, Pierce, Robert H, Choi, Jaehyuk, Chan, Timothy A, Koelle, David M, Nghiem, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472219/
https://www.ncbi.nlm.nih.gov/pubmed/36252564
http://dx.doi.org/10.1136/jitc-2022-005328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472219/
https://www.ncbi.nlm.nih.gov/pubmed/36252564
http://dx.doi.org/10.1136/jitc-2022-005328

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