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Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience
OBJECTIVE: The objective of the study is to describe the perioperative outcomes, disease-specific, and overall survival status in patients diagnosed with renal cell carcinoma with inferior vena cava (IVC) tumor thrombus. PATIENTS AND METHODS: We did a retrospective analysis of all patients who under...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472312/ https://www.ncbi.nlm.nih.gov/pubmed/36117789 http://dx.doi.org/10.4103/UA.UA_169_20 |
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author | Thangarasu, Mathisekaran Prakash, J. Sanjay Bafna, Sandeep Aarthy, P. Govindaswamy, Thirumalai Ganesan Venugopal, Balaji Sivaraman, Ananthakrishnan Jain, Nitesh Balakrishnan, Arunkumar Raghavan, Deepak Venkatraman, Murali Chandranathan, M. Paul, Rajesh Selvaraj, Nivash Ramakrishnan, Balasubramaniam Ragavan, Narasimhan |
author_facet | Thangarasu, Mathisekaran Prakash, J. Sanjay Bafna, Sandeep Aarthy, P. Govindaswamy, Thirumalai Ganesan Venugopal, Balaji Sivaraman, Ananthakrishnan Jain, Nitesh Balakrishnan, Arunkumar Raghavan, Deepak Venkatraman, Murali Chandranathan, M. Paul, Rajesh Selvaraj, Nivash Ramakrishnan, Balasubramaniam Ragavan, Narasimhan |
author_sort | Thangarasu, Mathisekaran |
collection | PubMed |
description | OBJECTIVE: The objective of the study is to describe the perioperative outcomes, disease-specific, and overall survival status in patients diagnosed with renal cell carcinoma with inferior vena cava (IVC) tumor thrombus. PATIENTS AND METHODS: We did a retrospective analysis of all patients who underwent radical nephrectomy along with IVC thrombectomy from the year 2013 to 2020. Mayo’s classification was used to stratify the level of IVC thrombus. Demographic, perioperative, histopathology data, complications, and survival status were analyzed. RESULTS: Total number of patients included in the study was 39, (Male: Female = 84.6%: 15.4%). Median age of patients was 58 (interquartile range [IQR] 50–63) years. Median size of renal tumor (in cms) was 9.5 (IQR 7.5–12), 8 (IQR 7–11.5), 8.5 (IQR 7–11.75), and 11 (IQR 9.5–11) (P = 0.998) in level 1,2,3, and 4 tumors, respectively. Clear cell variant was seen in 32 patients (82%) with R0 resection in 17 patients. Twelve patients (30.7%) had systemic metastasis on presentation. The overall mean survival time was 66.4 months with 95% confidence interval (CI) (52.4–80.5 months). Mean recurrence-free survival is 76 months with (63–90) CI of 95%. Mean survival in patients who presented with metastasis is 47 months with 95% CI (52.4–80.5). Perioperative mortality rate was 5.12% in this study. CONCLUSION: The tumor size does not have an influence on the progression of tumor thrombus into IVC. Significant difference in survival was observed between different levels of thrombus with high mortality in level four tumors. |
format | Online Article Text |
id | pubmed-9472312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-94723122022-09-15 Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience Thangarasu, Mathisekaran Prakash, J. Sanjay Bafna, Sandeep Aarthy, P. Govindaswamy, Thirumalai Ganesan Venugopal, Balaji Sivaraman, Ananthakrishnan Jain, Nitesh Balakrishnan, Arunkumar Raghavan, Deepak Venkatraman, Murali Chandranathan, M. Paul, Rajesh Selvaraj, Nivash Ramakrishnan, Balasubramaniam Ragavan, Narasimhan Urol Ann Original Article OBJECTIVE: The objective of the study is to describe the perioperative outcomes, disease-specific, and overall survival status in patients diagnosed with renal cell carcinoma with inferior vena cava (IVC) tumor thrombus. PATIENTS AND METHODS: We did a retrospective analysis of all patients who underwent radical nephrectomy along with IVC thrombectomy from the year 2013 to 2020. Mayo’s classification was used to stratify the level of IVC thrombus. Demographic, perioperative, histopathology data, complications, and survival status were analyzed. RESULTS: Total number of patients included in the study was 39, (Male: Female = 84.6%: 15.4%). Median age of patients was 58 (interquartile range [IQR] 50–63) years. Median size of renal tumor (in cms) was 9.5 (IQR 7.5–12), 8 (IQR 7–11.5), 8.5 (IQR 7–11.75), and 11 (IQR 9.5–11) (P = 0.998) in level 1,2,3, and 4 tumors, respectively. Clear cell variant was seen in 32 patients (82%) with R0 resection in 17 patients. Twelve patients (30.7%) had systemic metastasis on presentation. The overall mean survival time was 66.4 months with 95% confidence interval (CI) (52.4–80.5 months). Mean recurrence-free survival is 76 months with (63–90) CI of 95%. Mean survival in patients who presented with metastasis is 47 months with 95% CI (52.4–80.5). Perioperative mortality rate was 5.12% in this study. CONCLUSION: The tumor size does not have an influence on the progression of tumor thrombus into IVC. Significant difference in survival was observed between different levels of thrombus with high mortality in level four tumors. Wolters Kluwer - Medknow 2022 2022-07-18 /pmc/articles/PMC9472312/ /pubmed/36117789 http://dx.doi.org/10.4103/UA.UA_169_20 Text en Copyright: © 2022 Urology Annals https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Thangarasu, Mathisekaran Prakash, J. Sanjay Bafna, Sandeep Aarthy, P. Govindaswamy, Thirumalai Ganesan Venugopal, Balaji Sivaraman, Ananthakrishnan Jain, Nitesh Balakrishnan, Arunkumar Raghavan, Deepak Venkatraman, Murali Chandranathan, M. Paul, Rajesh Selvaraj, Nivash Ramakrishnan, Balasubramaniam Ragavan, Narasimhan Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience |
title | Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience |
title_full | Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience |
title_fullStr | Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience |
title_full_unstemmed | Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience |
title_short | Influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: A 7-year single-center experience |
title_sort | influence of tumor size in the progression of venous tumor thrombus in renal cell carcinoma: a 7-year single-center experience |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472312/ https://www.ncbi.nlm.nih.gov/pubmed/36117789 http://dx.doi.org/10.4103/UA.UA_169_20 |
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