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Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis
BACKGROUND: Diabetic foot ulcer (DFU) is one of the most serious diabetic complications. DFU is an open wound that usually occurs in the foot sole due to poor blood glucose control, peripheral neuropathy, and poor circulation. The human amniotic allograft membrane is a biological wound dressing deri...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472416/ https://www.ncbi.nlm.nih.gov/pubmed/36104736 http://dx.doi.org/10.1186/s13047-022-00575-y |
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author | Mohammed, Yasmine Adel Farouk, Hossam Khaled Gbreel, Mohamed Ibrahim Ali, Abdelrahman Mahmoud Salah, Ali Ashraf Nourelden, Anas Zakarya Gawad, Mohamed Mahmoud Abd-El |
author_facet | Mohammed, Yasmine Adel Farouk, Hossam Khaled Gbreel, Mohamed Ibrahim Ali, Abdelrahman Mahmoud Salah, Ali Ashraf Nourelden, Anas Zakarya Gawad, Mohamed Mahmoud Abd-El |
author_sort | Mohammed, Yasmine Adel |
collection | PubMed |
description | BACKGROUND: Diabetic foot ulcer (DFU) is one of the most serious diabetic complications. DFU is an open wound that usually occurs in the foot sole due to poor blood glucose control, peripheral neuropathy, and poor circulation. The human amniotic allograft membrane is a biological wound dressing derived from the amniotic membrane. It contains amino acids, nutrients, cytokines, and growth factors that make the growth process easier. OBJECTIVE: To compare dehydrated human amnion and chorion allograft (DHACA) plus the standard of wound care (SOC) with the SOC alone. METHODS: We searched for randomized clinical trials (RCTs) on PubMed, Scopus, Cochrane, and Web of Science till April 2021 using relevant keywords. All search results were screened for eligibility. We extracted the data from the included trials and pooled them as mean difference (MD) or risk ratio (RR) with the 95% confidence interval (CI) using Review Manager software (ver. 5.4). RESULTS: The pooled effect estimate from 11 RCTs showed that DHACA was superior to SOC regarding the complete wound healing in both 6th and 12th week (RR = 3.78; 95% CI: [2.51, 5.70]; P < 0.00001) and (RR = 2.00; 95% CI: [1.67, 2.39], P < 0.00001 respectively). Also, the analysis favored the DHACA regarding the mean time to heal in the 12th-week (MD = -12.07, 95%CI: [-19.23, -4.91], P = 0.001). The wound size reduction was better with DHACA (MD = 1.18, 95%CI: [-0,10, 2.26], P = 0.03). CONCLUSION: Using DHACA with SOC is safer and more effective than using SOC alone for DFU patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13047-022-00575-y. |
format | Online Article Text |
id | pubmed-9472416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94724162022-09-15 Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis Mohammed, Yasmine Adel Farouk, Hossam Khaled Gbreel, Mohamed Ibrahim Ali, Abdelrahman Mahmoud Salah, Ali Ashraf Nourelden, Anas Zakarya Gawad, Mohamed Mahmoud Abd-El J Foot Ankle Res Review BACKGROUND: Diabetic foot ulcer (DFU) is one of the most serious diabetic complications. DFU is an open wound that usually occurs in the foot sole due to poor blood glucose control, peripheral neuropathy, and poor circulation. The human amniotic allograft membrane is a biological wound dressing derived from the amniotic membrane. It contains amino acids, nutrients, cytokines, and growth factors that make the growth process easier. OBJECTIVE: To compare dehydrated human amnion and chorion allograft (DHACA) plus the standard of wound care (SOC) with the SOC alone. METHODS: We searched for randomized clinical trials (RCTs) on PubMed, Scopus, Cochrane, and Web of Science till April 2021 using relevant keywords. All search results were screened for eligibility. We extracted the data from the included trials and pooled them as mean difference (MD) or risk ratio (RR) with the 95% confidence interval (CI) using Review Manager software (ver. 5.4). RESULTS: The pooled effect estimate from 11 RCTs showed that DHACA was superior to SOC regarding the complete wound healing in both 6th and 12th week (RR = 3.78; 95% CI: [2.51, 5.70]; P < 0.00001) and (RR = 2.00; 95% CI: [1.67, 2.39], P < 0.00001 respectively). Also, the analysis favored the DHACA regarding the mean time to heal in the 12th-week (MD = -12.07, 95%CI: [-19.23, -4.91], P = 0.001). The wound size reduction was better with DHACA (MD = 1.18, 95%CI: [-0,10, 2.26], P = 0.03). CONCLUSION: Using DHACA with SOC is safer and more effective than using SOC alone for DFU patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13047-022-00575-y. BioMed Central 2022-09-14 /pmc/articles/PMC9472416/ /pubmed/36104736 http://dx.doi.org/10.1186/s13047-022-00575-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Mohammed, Yasmine Adel Farouk, Hossam Khaled Gbreel, Mohamed Ibrahim Ali, Abdelrahman Mahmoud Salah, Ali Ashraf Nourelden, Anas Zakarya Gawad, Mohamed Mahmoud Abd-El Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis |
title | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis |
title_full | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis |
title_fullStr | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis |
title_full_unstemmed | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis |
title_short | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis |
title_sort | human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472416/ https://www.ncbi.nlm.nih.gov/pubmed/36104736 http://dx.doi.org/10.1186/s13047-022-00575-y |
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