What are the prospects for durable immune control?

During the SARS CoV-2 primary infection, the neutralizing antibodies focused against the spike (S) glycoproteins are responsible for blockage of virus-host cell interaction. The cellular response mediated by CD4+ and CD8+ T-cells is responsible for control of viremia. Immune memory against SARS-CoV-...

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Detalles Bibliográficos
Autores principales: Lelievre, J.D., Bauer, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS. 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472462/
https://www.ncbi.nlm.nih.gov/pubmed/36113766
http://dx.doi.org/10.1016/j.idnow.2022.09.010
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author Lelievre, J.D.
Bauer, J.
author_facet Lelievre, J.D.
Bauer, J.
author_sort Lelievre, J.D.
collection PubMed
description During the SARS CoV-2 primary infection, the neutralizing antibodies focused against the spike (S) glycoproteins are responsible for blockage of virus-host cell interaction. The cellular response mediated by CD4+ and CD8+ T-cells is responsible for control of viremia. Immune memory against SARS-CoV-2 depends on virus type, replication kinetics and route of penetration. The formation and persistence of germinal centers are critical for the generation of affinity-matured plasma cells and memory B cells capable of mediating durable immunity. They can persist up to 30 weeks after vaccination and several months after infection. Heterogeneity in the longevity of the vaccination-induced GC response is significant.
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spelling pubmed-94724622022-09-14 What are the prospects for durable immune control? Lelievre, J.D. Bauer, J. Infect Dis Now Original Article During the SARS CoV-2 primary infection, the neutralizing antibodies focused against the spike (S) glycoproteins are responsible for blockage of virus-host cell interaction. The cellular response mediated by CD4+ and CD8+ T-cells is responsible for control of viremia. Immune memory against SARS-CoV-2 depends on virus type, replication kinetics and route of penetration. The formation and persistence of germinal centers are critical for the generation of affinity-matured plasma cells and memory B cells capable of mediating durable immunity. They can persist up to 30 weeks after vaccination and several months after infection. Heterogeneity in the longevity of the vaccination-induced GC response is significant. Published by Elsevier Masson SAS. 2022-11 2022-09-13 /pmc/articles/PMC9472462/ /pubmed/36113766 http://dx.doi.org/10.1016/j.idnow.2022.09.010 Text en © 2022 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Lelievre, J.D.
Bauer, J.
What are the prospects for durable immune control?
title What are the prospects for durable immune control?
title_full What are the prospects for durable immune control?
title_fullStr What are the prospects for durable immune control?
title_full_unstemmed What are the prospects for durable immune control?
title_short What are the prospects for durable immune control?
title_sort what are the prospects for durable immune control?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472462/
https://www.ncbi.nlm.nih.gov/pubmed/36113766
http://dx.doi.org/10.1016/j.idnow.2022.09.010
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