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Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study

OBJECTIVE: To estimate the association and familial coaggregation of childhood-onset type 1 diabetes with depression, anxiety, and stress-related disorders. RESEARCH DESIGN AND METHODS: This was a population-based cohort study with use of data from Swedish nationwide registers. A total of ∼3.5 milli...

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Autores principales: Liu, Shengxin, Leone, Marica, Ludvigsson, Jonas F., Lichtenstein, Paul, D’Onofrio, Brian, Svensson, Ann-Marie, Gudbjörnsdottir, Soffia, Bergen, Sarah E., Larsson, Henrik, Kuja-Halkola, Ralf, Butwicka, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472496/
https://www.ncbi.nlm.nih.gov/pubmed/35913075
http://dx.doi.org/10.2337/dc21-1347
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author Liu, Shengxin
Leone, Marica
Ludvigsson, Jonas F.
Lichtenstein, Paul
D’Onofrio, Brian
Svensson, Ann-Marie
Gudbjörnsdottir, Soffia
Bergen, Sarah E.
Larsson, Henrik
Kuja-Halkola, Ralf
Butwicka, Agnieszka
author_facet Liu, Shengxin
Leone, Marica
Ludvigsson, Jonas F.
Lichtenstein, Paul
D’Onofrio, Brian
Svensson, Ann-Marie
Gudbjörnsdottir, Soffia
Bergen, Sarah E.
Larsson, Henrik
Kuja-Halkola, Ralf
Butwicka, Agnieszka
author_sort Liu, Shengxin
collection PubMed
description OBJECTIVE: To estimate the association and familial coaggregation of childhood-onset type 1 diabetes with depression, anxiety, and stress-related disorders. RESEARCH DESIGN AND METHODS: This was a population-based cohort study with use of data from Swedish nationwide registers. A total of ∼3.5 million individuals born in Sweden 1973–2007 were linked to their biological parents, full siblings and half-siblings, and cousins. Cox models were used to estimate the association and familial coaggregation of type 1 diabetes with depression, anxiety, and stress-related disorders. RESULTS: Individuals diagnosed with childhood-onset type 1 diabetes (n = 20,005) were found to be at greater risks of all outcomes: any psychiatric diagnosis (adjusted hazard ratio [aHR] 1.66 [95% CI 1.59–1.72]) or specific diagnoses of depression (1.85 [1.76–1.94]), anxiety (1.41[1.33–1.50]), and stress-related disorders (1.75 [1.62–1.89]), as well as use of antidepressants or anxiolytics (1.30 [1.26–1.34]), compared with individuals without type 1 diabetes. Overall, relatives of individuals with type 1 diabetes were at elevated risks of developing these outcomes, with the highest risks seen in parents (aHRs 1.18–1.25), followed by full siblings (aHRs 1.05–1.20), and the magnitudes of risk estimates appear proportional to familial relatedness. CONCLUSIONS: These results support existing evidence that children and adolescents with type 1 diabetes are at greater risks of developing depression, anxiety, and stress-related disorders and indicate that shared familial factors might contribute to these elevated risks. Our findings highlight the need for psychological consulting for children and their families in diabetes care. Quantitative and molecular genetic studies are warranted to further understand the etiology of these psychiatric disorders in type 1 diabetes.
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spelling pubmed-94724962022-10-14 Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study Liu, Shengxin Leone, Marica Ludvigsson, Jonas F. Lichtenstein, Paul D’Onofrio, Brian Svensson, Ann-Marie Gudbjörnsdottir, Soffia Bergen, Sarah E. Larsson, Henrik Kuja-Halkola, Ralf Butwicka, Agnieszka Diabetes Care Epidemiology/Health Services Research OBJECTIVE: To estimate the association and familial coaggregation of childhood-onset type 1 diabetes with depression, anxiety, and stress-related disorders. RESEARCH DESIGN AND METHODS: This was a population-based cohort study with use of data from Swedish nationwide registers. A total of ∼3.5 million individuals born in Sweden 1973–2007 were linked to their biological parents, full siblings and half-siblings, and cousins. Cox models were used to estimate the association and familial coaggregation of type 1 diabetes with depression, anxiety, and stress-related disorders. RESULTS: Individuals diagnosed with childhood-onset type 1 diabetes (n = 20,005) were found to be at greater risks of all outcomes: any psychiatric diagnosis (adjusted hazard ratio [aHR] 1.66 [95% CI 1.59–1.72]) or specific diagnoses of depression (1.85 [1.76–1.94]), anxiety (1.41[1.33–1.50]), and stress-related disorders (1.75 [1.62–1.89]), as well as use of antidepressants or anxiolytics (1.30 [1.26–1.34]), compared with individuals without type 1 diabetes. Overall, relatives of individuals with type 1 diabetes were at elevated risks of developing these outcomes, with the highest risks seen in parents (aHRs 1.18–1.25), followed by full siblings (aHRs 1.05–1.20), and the magnitudes of risk estimates appear proportional to familial relatedness. CONCLUSIONS: These results support existing evidence that children and adolescents with type 1 diabetes are at greater risks of developing depression, anxiety, and stress-related disorders and indicate that shared familial factors might contribute to these elevated risks. Our findings highlight the need for psychological consulting for children and their families in diabetes care. Quantitative and molecular genetic studies are warranted to further understand the etiology of these psychiatric disorders in type 1 diabetes. American Diabetes Association 2022-09 2022-08-01 /pmc/articles/PMC9472496/ /pubmed/35913075 http://dx.doi.org/10.2337/dc21-1347 Text en © 2022 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/journals/pages/license.
spellingShingle Epidemiology/Health Services Research
Liu, Shengxin
Leone, Marica
Ludvigsson, Jonas F.
Lichtenstein, Paul
D’Onofrio, Brian
Svensson, Ann-Marie
Gudbjörnsdottir, Soffia
Bergen, Sarah E.
Larsson, Henrik
Kuja-Halkola, Ralf
Butwicka, Agnieszka
Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study
title Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study
title_full Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study
title_fullStr Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study
title_full_unstemmed Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study
title_short Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study
title_sort association and familial coaggregation of childhood-onset type 1 diabetes with depression, anxiety, and stress-related disorders: a population-based cohort study
topic Epidemiology/Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472496/
https://www.ncbi.nlm.nih.gov/pubmed/35913075
http://dx.doi.org/10.2337/dc21-1347
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