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Influence of sex on survival rates of HPV-positive oropharyngeal cancers

The role of human papillomavirus (HPV) status for the prognosis of oropharyngeal cancers (OPCs) is discussed controversially. Here, we present an analysis of 144,969 head and neck cancer cases (ICD-10 codes: C00–C13) with a sub-cohort of 62,775 tumor cases of the oropharynx (C01, C09, and C10). To t...

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Autores principales: Preissner, Sally H., Nahles, Susanne, Preissner, Saskia, Heiland, Max, Koerdt, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472547/
https://www.ncbi.nlm.nih.gov/pubmed/36119465
http://dx.doi.org/10.3389/fonc.2022.917890
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author Preissner, Sally H.
Nahles, Susanne
Preissner, Saskia
Heiland, Max
Koerdt, Steffen
author_facet Preissner, Sally H.
Nahles, Susanne
Preissner, Saskia
Heiland, Max
Koerdt, Steffen
author_sort Preissner, Sally H.
collection PubMed
description The role of human papillomavirus (HPV) status for the prognosis of oropharyngeal cancers (OPCs) is discussed controversially. Here, we present an analysis of 144,969 head and neck cancer cases (ICD-10 codes: C00–C13) with a sub-cohort of 62,775 tumor cases of the oropharynx (C01, C09, and C10). To this end, de-identified data from electronic health records of about 60 healthcare organizations from 30 different countries were used. Odds ratios, hazard ratios (HRs), and Kaplan–Meier analyses were used to compare outcomes between different cancer entities of neoplasms of the base of the tongue (C01), of tonsils (C09), and of the oropharynx (C10) of women and men with and without HPV infection. To avoid the bias from different age distributions, the cohorts were balanced using propensity score matching. The 5-year survival rate for HPV-positive patients is somewhat better than that for HPV-negative patients, but for age- and sex-balanced cohorts, there remains no significant advantage for HPV-positive patients [HR, 1.126 (0.897–1.413)]. Looking at the different entities and HPV status for age-matched male and female patients separately, HPV is a significantly positive prognostic factor for female patients in some entities, whereas for male patients, it is only a positive prognostic factor for malignant neoplasms of oropharynx (C10) [HR, 1.077 (0.602–1.926)].
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spelling pubmed-94725472022-09-15 Influence of sex on survival rates of HPV-positive oropharyngeal cancers Preissner, Sally H. Nahles, Susanne Preissner, Saskia Heiland, Max Koerdt, Steffen Front Oncol Oncology The role of human papillomavirus (HPV) status for the prognosis of oropharyngeal cancers (OPCs) is discussed controversially. Here, we present an analysis of 144,969 head and neck cancer cases (ICD-10 codes: C00–C13) with a sub-cohort of 62,775 tumor cases of the oropharynx (C01, C09, and C10). To this end, de-identified data from electronic health records of about 60 healthcare organizations from 30 different countries were used. Odds ratios, hazard ratios (HRs), and Kaplan–Meier analyses were used to compare outcomes between different cancer entities of neoplasms of the base of the tongue (C01), of tonsils (C09), and of the oropharynx (C10) of women and men with and without HPV infection. To avoid the bias from different age distributions, the cohorts were balanced using propensity score matching. The 5-year survival rate for HPV-positive patients is somewhat better than that for HPV-negative patients, but for age- and sex-balanced cohorts, there remains no significant advantage for HPV-positive patients [HR, 1.126 (0.897–1.413)]. Looking at the different entities and HPV status for age-matched male and female patients separately, HPV is a significantly positive prognostic factor for female patients in some entities, whereas for male patients, it is only a positive prognostic factor for malignant neoplasms of oropharynx (C10) [HR, 1.077 (0.602–1.926)]. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9472547/ /pubmed/36119465 http://dx.doi.org/10.3389/fonc.2022.917890 Text en Copyright © 2022 Preissner, Nahles, Preissner, Heiland and Koerdt https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Preissner, Sally H.
Nahles, Susanne
Preissner, Saskia
Heiland, Max
Koerdt, Steffen
Influence of sex on survival rates of HPV-positive oropharyngeal cancers
title Influence of sex on survival rates of HPV-positive oropharyngeal cancers
title_full Influence of sex on survival rates of HPV-positive oropharyngeal cancers
title_fullStr Influence of sex on survival rates of HPV-positive oropharyngeal cancers
title_full_unstemmed Influence of sex on survival rates of HPV-positive oropharyngeal cancers
title_short Influence of sex on survival rates of HPV-positive oropharyngeal cancers
title_sort influence of sex on survival rates of hpv-positive oropharyngeal cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472547/
https://www.ncbi.nlm.nih.gov/pubmed/36119465
http://dx.doi.org/10.3389/fonc.2022.917890
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