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Influence of sex on survival rates of HPV-positive oropharyngeal cancers
The role of human papillomavirus (HPV) status for the prognosis of oropharyngeal cancers (OPCs) is discussed controversially. Here, we present an analysis of 144,969 head and neck cancer cases (ICD-10 codes: C00–C13) with a sub-cohort of 62,775 tumor cases of the oropharynx (C01, C09, and C10). To t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472547/ https://www.ncbi.nlm.nih.gov/pubmed/36119465 http://dx.doi.org/10.3389/fonc.2022.917890 |
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author | Preissner, Sally H. Nahles, Susanne Preissner, Saskia Heiland, Max Koerdt, Steffen |
author_facet | Preissner, Sally H. Nahles, Susanne Preissner, Saskia Heiland, Max Koerdt, Steffen |
author_sort | Preissner, Sally H. |
collection | PubMed |
description | The role of human papillomavirus (HPV) status for the prognosis of oropharyngeal cancers (OPCs) is discussed controversially. Here, we present an analysis of 144,969 head and neck cancer cases (ICD-10 codes: C00–C13) with a sub-cohort of 62,775 tumor cases of the oropharynx (C01, C09, and C10). To this end, de-identified data from electronic health records of about 60 healthcare organizations from 30 different countries were used. Odds ratios, hazard ratios (HRs), and Kaplan–Meier analyses were used to compare outcomes between different cancer entities of neoplasms of the base of the tongue (C01), of tonsils (C09), and of the oropharynx (C10) of women and men with and without HPV infection. To avoid the bias from different age distributions, the cohorts were balanced using propensity score matching. The 5-year survival rate for HPV-positive patients is somewhat better than that for HPV-negative patients, but for age- and sex-balanced cohorts, there remains no significant advantage for HPV-positive patients [HR, 1.126 (0.897–1.413)]. Looking at the different entities and HPV status for age-matched male and female patients separately, HPV is a significantly positive prognostic factor for female patients in some entities, whereas for male patients, it is only a positive prognostic factor for malignant neoplasms of oropharynx (C10) [HR, 1.077 (0.602–1.926)]. |
format | Online Article Text |
id | pubmed-9472547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94725472022-09-15 Influence of sex on survival rates of HPV-positive oropharyngeal cancers Preissner, Sally H. Nahles, Susanne Preissner, Saskia Heiland, Max Koerdt, Steffen Front Oncol Oncology The role of human papillomavirus (HPV) status for the prognosis of oropharyngeal cancers (OPCs) is discussed controversially. Here, we present an analysis of 144,969 head and neck cancer cases (ICD-10 codes: C00–C13) with a sub-cohort of 62,775 tumor cases of the oropharynx (C01, C09, and C10). To this end, de-identified data from electronic health records of about 60 healthcare organizations from 30 different countries were used. Odds ratios, hazard ratios (HRs), and Kaplan–Meier analyses were used to compare outcomes between different cancer entities of neoplasms of the base of the tongue (C01), of tonsils (C09), and of the oropharynx (C10) of women and men with and without HPV infection. To avoid the bias from different age distributions, the cohorts were balanced using propensity score matching. The 5-year survival rate for HPV-positive patients is somewhat better than that for HPV-negative patients, but for age- and sex-balanced cohorts, there remains no significant advantage for HPV-positive patients [HR, 1.126 (0.897–1.413)]. Looking at the different entities and HPV status for age-matched male and female patients separately, HPV is a significantly positive prognostic factor for female patients in some entities, whereas for male patients, it is only a positive prognostic factor for malignant neoplasms of oropharynx (C10) [HR, 1.077 (0.602–1.926)]. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9472547/ /pubmed/36119465 http://dx.doi.org/10.3389/fonc.2022.917890 Text en Copyright © 2022 Preissner, Nahles, Preissner, Heiland and Koerdt https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Preissner, Sally H. Nahles, Susanne Preissner, Saskia Heiland, Max Koerdt, Steffen Influence of sex on survival rates of HPV-positive oropharyngeal cancers |
title | Influence of sex on survival rates of HPV-positive oropharyngeal cancers |
title_full | Influence of sex on survival rates of HPV-positive oropharyngeal cancers |
title_fullStr | Influence of sex on survival rates of HPV-positive oropharyngeal cancers |
title_full_unstemmed | Influence of sex on survival rates of HPV-positive oropharyngeal cancers |
title_short | Influence of sex on survival rates of HPV-positive oropharyngeal cancers |
title_sort | influence of sex on survival rates of hpv-positive oropharyngeal cancers |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472547/ https://www.ncbi.nlm.nih.gov/pubmed/36119465 http://dx.doi.org/10.3389/fonc.2022.917890 |
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