Variations in Cell Surface ACE2 Levels Alter Direct Binding of SARS-CoV-2 Spike Protein and Viral Infectivity: Implications for Measuring Spike Protein Interactions with Animal ACE2 Orthologs

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), the most severe pandemic in a century. The virus gains access to host cells when the viral spike protein (S-protein) binds to the host cell surface receptor angiotensin-convert...

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Detalles Bibliográficos
Autores principales: Kazemi, Soheila, López-Muñoz, Alberto Domingo, Hollý, Jaroslav, Jin, Ling, Yewdell, Jonathan W., Dolan, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472623/
https://www.ncbi.nlm.nih.gov/pubmed/36000847
http://dx.doi.org/10.1128/jvi.00256-22
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