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Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5
After the global spread of the SARS-CoV-2 Omicron BA.2, some BA.2 subvariants, including BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical analysis showed that the effective reproduction numbers of these BA.2 subvariants are greater than that of the origina...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Author(s). Published by Elsevier Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472642/ https://www.ncbi.nlm.nih.gov/pubmed/36198317 http://dx.doi.org/10.1016/j.cell.2022.09.018 |
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| author | Kimura, Izumi Yamasoba, Daichi Tamura, Tomokazu Nao, Naganori Suzuki, Tateki Oda, Yoshitaka Mitoma, Shuya Ito, Jumpei Nasser, Hesham Zahradnik, Jiri Uriu, Keiya Fujita, Shigeru Kosugi, Yusuke Wang, Lei Tsuda, Masumi Kishimoto, Mai Ito, Hayato Suzuki, Rigel Shimizu, Ryo Begum, MST Monira Yoshimatsu, Kumiko Kimura, Kanako Terakado Sasaki, Jiei Sasaki-Tabata, Kaori Yamamoto, Yuki Nagamoto, Tetsuharu Kanamune, Jun Kobiyama, Kouji Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Shirakawa, Kotaro Takaori-Kondo, Akifumi Kuramochi, Jin Schreiber, Gideon Ishii, Ken J. Hashiguchi, Takao Ikeda, Terumasa Saito, Akatsuki Fukuhara, Takasuke Tanaka, Shinya Matsuno, Keita Sato, Kei |
| author_facet | Kimura, Izumi Yamasoba, Daichi Tamura, Tomokazu Nao, Naganori Suzuki, Tateki Oda, Yoshitaka Mitoma, Shuya Ito, Jumpei Nasser, Hesham Zahradnik, Jiri Uriu, Keiya Fujita, Shigeru Kosugi, Yusuke Wang, Lei Tsuda, Masumi Kishimoto, Mai Ito, Hayato Suzuki, Rigel Shimizu, Ryo Begum, MST Monira Yoshimatsu, Kumiko Kimura, Kanako Terakado Sasaki, Jiei Sasaki-Tabata, Kaori Yamamoto, Yuki Nagamoto, Tetsuharu Kanamune, Jun Kobiyama, Kouji Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Shirakawa, Kotaro Takaori-Kondo, Akifumi Kuramochi, Jin Schreiber, Gideon Ishii, Ken J. Hashiguchi, Takao Ikeda, Terumasa Saito, Akatsuki Fukuhara, Takasuke Tanaka, Shinya Matsuno, Keita Sato, Kei |
| author_sort | Kimura, Izumi |
| collection | PubMed |
| description | After the global spread of the SARS-CoV-2 Omicron BA.2, some BA.2 subvariants, including BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical analysis showed that the effective reproduction numbers of these BA.2 subvariants are greater than that of the original BA.2. Neutralization experiments revealed that the immunity induced by BA.1/2 infections is less effective against BA.4/5. Cell culture experiments showed that BA.2.12.1 and BA.4/5 replicate more efficiently in human alveolar epithelial cells than BA.2, and particularly, BA.4/5 is more fusogenic than BA.2. We further provided the structure of the BA.4/5 spike receptor-binding domain that binds to human ACE2 and considered how the substitutions in the BA.4/5 spike play roles in ACE2 binding and immune evasion. Moreover, experiments using hamsters suggested that BA.4/5 is more pathogenic than BA.2. Our multiscale investigations suggest that the risk of BA.2 subvariants, particularly BA.4/5, to global health is greater than that of original BA.2. |
| format | Online Article Text |
| id | pubmed-9472642 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | The Author(s). Published by Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94726422022-09-14 Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 Kimura, Izumi Yamasoba, Daichi Tamura, Tomokazu Nao, Naganori Suzuki, Tateki Oda, Yoshitaka Mitoma, Shuya Ito, Jumpei Nasser, Hesham Zahradnik, Jiri Uriu, Keiya Fujita, Shigeru Kosugi, Yusuke Wang, Lei Tsuda, Masumi Kishimoto, Mai Ito, Hayato Suzuki, Rigel Shimizu, Ryo Begum, MST Monira Yoshimatsu, Kumiko Kimura, Kanako Terakado Sasaki, Jiei Sasaki-Tabata, Kaori Yamamoto, Yuki Nagamoto, Tetsuharu Kanamune, Jun Kobiyama, Kouji Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Shirakawa, Kotaro Takaori-Kondo, Akifumi Kuramochi, Jin Schreiber, Gideon Ishii, Ken J. Hashiguchi, Takao Ikeda, Terumasa Saito, Akatsuki Fukuhara, Takasuke Tanaka, Shinya Matsuno, Keita Sato, Kei Cell Article After the global spread of the SARS-CoV-2 Omicron BA.2, some BA.2 subvariants, including BA.2.9.1, BA.2.11, BA.2.12.1, BA.4, and BA.5, emerged in multiple countries. Our statistical analysis showed that the effective reproduction numbers of these BA.2 subvariants are greater than that of the original BA.2. Neutralization experiments revealed that the immunity induced by BA.1/2 infections is less effective against BA.4/5. Cell culture experiments showed that BA.2.12.1 and BA.4/5 replicate more efficiently in human alveolar epithelial cells than BA.2, and particularly, BA.4/5 is more fusogenic than BA.2. We further provided the structure of the BA.4/5 spike receptor-binding domain that binds to human ACE2 and considered how the substitutions in the BA.4/5 spike play roles in ACE2 binding and immune evasion. Moreover, experiments using hamsters suggested that BA.4/5 is more pathogenic than BA.2. Our multiscale investigations suggest that the risk of BA.2 subvariants, particularly BA.4/5, to global health is greater than that of original BA.2. The Author(s). Published by Elsevier Inc. 2022-10-13 2022-09-14 /pmc/articles/PMC9472642/ /pubmed/36198317 http://dx.doi.org/10.1016/j.cell.2022.09.018 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Kimura, Izumi Yamasoba, Daichi Tamura, Tomokazu Nao, Naganori Suzuki, Tateki Oda, Yoshitaka Mitoma, Shuya Ito, Jumpei Nasser, Hesham Zahradnik, Jiri Uriu, Keiya Fujita, Shigeru Kosugi, Yusuke Wang, Lei Tsuda, Masumi Kishimoto, Mai Ito, Hayato Suzuki, Rigel Shimizu, Ryo Begum, MST Monira Yoshimatsu, Kumiko Kimura, Kanako Terakado Sasaki, Jiei Sasaki-Tabata, Kaori Yamamoto, Yuki Nagamoto, Tetsuharu Kanamune, Jun Kobiyama, Kouji Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Shirakawa, Kotaro Takaori-Kondo, Akifumi Kuramochi, Jin Schreiber, Gideon Ishii, Ken J. Hashiguchi, Takao Ikeda, Terumasa Saito, Akatsuki Fukuhara, Takasuke Tanaka, Shinya Matsuno, Keita Sato, Kei Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 |
| title | Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 |
| title_full | Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 |
| title_fullStr | Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 |
| title_full_unstemmed | Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 |
| title_short | Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 |
| title_sort | virological characteristics of the sars-cov-2 omicron ba.2 subvariants, including ba.4 and ba.5 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472642/ https://www.ncbi.nlm.nih.gov/pubmed/36198317 http://dx.doi.org/10.1016/j.cell.2022.09.018 |
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