Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy

An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of neg...

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Detalles Bibliográficos
Autores principales: Jiang, Qian, Chen, Xiaobing, Liang, Hong, Nie, Yu, Jin, Rongrong, Barz, Matthias, Yue, Dong, Gu, Zhongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473180/
https://www.ncbi.nlm.nih.gov/pubmed/36132232
http://dx.doi.org/10.1039/c8na00191j
Descripción
Sumario:An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.

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