Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy

An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of neg...

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Detalles Bibliográficos
Autores principales: Jiang, Qian, Chen, Xiaobing, Liang, Hong, Nie, Yu, Jin, Rongrong, Barz, Matthias, Yue, Dong, Gu, Zhongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473180/
https://www.ncbi.nlm.nih.gov/pubmed/36132232
http://dx.doi.org/10.1039/c8na00191j
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author Jiang, Qian
Chen, Xiaobing
Liang, Hong
Nie, Yu
Jin, Rongrong
Barz, Matthias
Yue, Dong
Gu, Zhongwei
author_facet Jiang, Qian
Chen, Xiaobing
Liang, Hong
Nie, Yu
Jin, Rongrong
Barz, Matthias
Yue, Dong
Gu, Zhongwei
author_sort Jiang, Qian
collection PubMed
description An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect.
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spelling pubmed-94731802022-09-20 Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy Jiang, Qian Chen, Xiaobing Liang, Hong Nie, Yu Jin, Rongrong Barz, Matthias Yue, Dong Gu, Zhongwei Nanoscale Adv Chemistry An integrated peptide-camptothecin prodrug (RSC) system was designed as a nano-sized multistage rocket for the efficient complexation and controlled sequential release of siRNA and anticancer drug under tumor-relevant reductive and esterase-enriched conditions, which facilitated the avoidance of negative interactions and maximized the synergistic effect. RSC 2018-10-20 /pmc/articles/PMC9473180/ /pubmed/36132232 http://dx.doi.org/10.1039/c8na00191j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jiang, Qian
Chen, Xiaobing
Liang, Hong
Nie, Yu
Jin, Rongrong
Barz, Matthias
Yue, Dong
Gu, Zhongwei
Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
title Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
title_full Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
title_fullStr Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
title_full_unstemmed Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
title_short Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
title_sort multistage rocket: integrational design of a prodrug-based sirna delivery system with sequential release for enhanced antitumor efficacy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473180/
https://www.ncbi.nlm.nih.gov/pubmed/36132232
http://dx.doi.org/10.1039/c8na00191j
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