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Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function

Multidrug resistance (MDR) is thought to be one of the main reasons for the failure of chemotherapy in cancers. ATP-binding cassette subfamily B member 1 (ABCB1) or P-glycoprotein (P-gp) and ATP-binding cassette subfamily G member 2 (ABCG2) play indispensable roles in cancer cell MDR. Sigma-2 (σ(2))...

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Detalles Bibliográficos
Autores principales:	Zeng, Zhanwei, Liao, Shiyi, Zhou, Huan, Liu, Hongyu, Lin, Jiantao, Huang, Yunsheng, Zhou, Chenhui, Xu, Daohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473340/ https://www.ncbi.nlm.nih.gov/pubmed/36120340 http://dx.doi.org/10.3389/fphar.2022.952980

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