Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants

We recently published a preliminary assessment of the activity of a poly (ADP-ribose) polymerase (PARP) inhibitor, stenoparib, also known as 2X-121, which inhibits viral replication by affecting pathways of the host. Here we show that stenoparib effectively inhibits a SARS-CoV-2 wild type (BavPat1/2...

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Detalles Bibliográficos
Autores principales: Zarn, Katherine E., Jaramillo, Sierra A., Zapata, Anthony R., Stone, Nathan E., Jones, Ashley N., Nunnally, Haley E., Settles, Erik W., Ng, Ken, Keim, Paul S., Knudsen, Steen, Nuijten, Patricia M., Tijsma, Aloys S. L., French, Christopher T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473406/
https://www.ncbi.nlm.nih.gov/pubmed/36103462
http://dx.doi.org/10.1371/journal.pone.0272916

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