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DFV890: a new oral NLRP3 inhibitor—tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function
BACKGROUND: Coronavirus-associated acute respiratory distress syndrome (CARDS) has limited effective therapy to date. NLRP3 inflammasome activation induced by SARS-CoV-2 in COVID-19 contributes to cytokine storm. METHODS: This randomised, multinational study enrolled hospitalised patients (18–80 yea...
Autores principales: | Madurka, Ildiko, Vishnevsky, Alexander, Soriano, Joan B., Gans, Stephanus J., Ore, Danilo Joel Salazar, Rendon, Adrian, Ulrik, Charlotte S., Bhatnagar, Sushma, Krishnamurthy, Srikanth, Mc Harry, Kirsten, Welte, Tobias, Fernandez, Alberto A., Mehes, Beata, Meiser, Karin, Gatlik, Ewa, Sommer, Ulrike, Junge, Guido, Rezende, Ederlon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473473/ https://www.ncbi.nlm.nih.gov/pubmed/36104613 http://dx.doi.org/10.1007/s15010-022-01904-w |
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