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Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein

The conformational conversion of the cellular prion protein (PrP(C)) into a misfolded, aggregated and infectious scrapie isoform is associated with prion disease pathology and neurodegeneration. Despite the significant number of experimental and theoretical studies the molecular mechanism regulating...

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Detalles Bibliográficos
Autores principales:	Russo, Luigi, Salzano, Giulia, Corvino, Andrea, Bistaffa, Edoardo, Moda, Fabio, Celauro, Luigi, D'Abrosca, Gianluca, Isernia, Carla, Milardi, Danilo, Giachin, Gabriele, Malgieri, Gaetano, Legname, Giuseppe, Fattorusso, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473526/ https://www.ncbi.nlm.nih.gov/pubmed/36277622 http://dx.doi.org/10.1039/d2sc00345g

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