Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces mild or asymptomatic COVID-19 in most cases, but some patients develop an excessive inflammatory process that can be fatal. As the NLRP3 inflammasome and additional inflammasomes are implicated in disease aggravation, drug repositi...

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Detalles Bibliográficos
Autores principales: de Almeida, Letícia, da Silva, Alexandre L. N., Rodrigues, Tamara S., Oliveira, Samuel, Ishimoto, Adriene Y., Seribelli, Amanda A., Becerra, Amanda, Andrade, Warrison A., Ataide, Marco A., Caetano, Camila C. S., de Sá, Keyla S. G., Pelisson, Natália, Martins, Ronaldo B., de Paula Souza, Juliano, Arruda, Eurico, Batah, Sabrina S., Castro, Ricardo, Frantz, Fabiani G., Cunha, Fernando Q., Cunha, Thiago M., Fabro, Alexandre T., Cunha, Larissa D., Louzada-Junior, Paulo, de Oliveira, Rene D. R., Zamboni, Dario S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473568/
https://www.ncbi.nlm.nih.gov/pubmed/36103544
http://dx.doi.org/10.1126/sciadv.abo5400

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