Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

The mechanism of action of eprenetapopt (APR-246, PRIMA-1(MET)) as an anticancer agent remains unresolved, although the clinical development of eprenetapopt focuses on its reported mechanism of action as a mutant-p53 reactivator. Using unbiased approaches, this study demonstrates that eprenetapopt d...

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Detalles Bibliográficos
Autores principales: Fujihara, Kenji M., Zhang, Bonnie Z., Jackson, Thomas D., Ogunkola, Moses O., Nijagal, Brunda, Milne, Julia V., Sallman, David A., Ang, Ching-Seng, Nikolic, Iva, Kearney, Conor J., Hogg, Simon J., Cabalag, Carlos S., Sutton, Vivien R., Watt, Sally, Fujihara, Asuka T., Trapani, Joseph A., Simpson, Kaylene J., Stojanovski, Diana, Leimkühler, Silke, Haupt, Sue, Phillips, Wayne A., Clemons, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473576/
https://www.ncbi.nlm.nih.gov/pubmed/36103522
http://dx.doi.org/10.1126/sciadv.abm9427

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