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Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining mental health and resistance to stress, and omega-3 PUFAs supplementation can display beneficial effects on both the prevention and treatment of depressive disorders. Although the underlying mechanisms are still uncl...

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Autores principales: Zhou, Lie, Xiong, Jia-Yao, Chai, Yu-Qian, Huang, Lu, Tang, Zi-Yang, Zhang, Xin-Feng, Liu, Bo, Zhang, Jun-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473681/
https://www.ncbi.nlm.nih.gov/pubmed/36117650
http://dx.doi.org/10.3389/fpsyt.2022.933704
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author Zhou, Lie
Xiong, Jia-Yao
Chai, Yu-Qian
Huang, Lu
Tang, Zi-Yang
Zhang, Xin-Feng
Liu, Bo
Zhang, Jun-Tao
author_facet Zhou, Lie
Xiong, Jia-Yao
Chai, Yu-Qian
Huang, Lu
Tang, Zi-Yang
Zhang, Xin-Feng
Liu, Bo
Zhang, Jun-Tao
author_sort Zhou, Lie
collection PubMed
description Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining mental health and resistance to stress, and omega-3 PUFAs supplementation can display beneficial effects on both the prevention and treatment of depressive disorders. Although the underlying mechanisms are still unclear, accumulated evidence indicates that omega-3 PUFAs can exhibit pleiotropic effects on the neural structure and function. Thus, they play fundamental roles in brain activities involved in the mood regulation. Since depressive symptoms have been assumed to be of central origin, this review aims to summarize the recently published studies to identify the potential neurobiological mechanisms underlying the anti-depressant effects of omega-3 PUFAs. These include that of (1) anti-neuroinflammatory; (2) hypothalamus-pituitary-adrenal (HPA) axis; (3) anti-oxidative stress; (4) anti-neurodegeneration; (5) neuroplasticity and synaptic plasticity; and (6) modulation of neurotransmitter systems. Despite many lines of evidence have hinted that these mechanisms may co-exist and work in concert to produce anti-depressive effects, the potentially multiple sites of action of omega-3 PUFAs need to be fully established. We also discussed the limitations of current studies and suggest future directions for preclinical and translational research in this field.
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spelling pubmed-94736812022-09-15 Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system Zhou, Lie Xiong, Jia-Yao Chai, Yu-Qian Huang, Lu Tang, Zi-Yang Zhang, Xin-Feng Liu, Bo Zhang, Jun-Tao Front Psychiatry Psychiatry Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining mental health and resistance to stress, and omega-3 PUFAs supplementation can display beneficial effects on both the prevention and treatment of depressive disorders. Although the underlying mechanisms are still unclear, accumulated evidence indicates that omega-3 PUFAs can exhibit pleiotropic effects on the neural structure and function. Thus, they play fundamental roles in brain activities involved in the mood regulation. Since depressive symptoms have been assumed to be of central origin, this review aims to summarize the recently published studies to identify the potential neurobiological mechanisms underlying the anti-depressant effects of omega-3 PUFAs. These include that of (1) anti-neuroinflammatory; (2) hypothalamus-pituitary-adrenal (HPA) axis; (3) anti-oxidative stress; (4) anti-neurodegeneration; (5) neuroplasticity and synaptic plasticity; and (6) modulation of neurotransmitter systems. Despite many lines of evidence have hinted that these mechanisms may co-exist and work in concert to produce anti-depressive effects, the potentially multiple sites of action of omega-3 PUFAs need to be fully established. We also discussed the limitations of current studies and suggest future directions for preclinical and translational research in this field. Frontiers Media S.A. 2022-08-31 /pmc/articles/PMC9473681/ /pubmed/36117650 http://dx.doi.org/10.3389/fpsyt.2022.933704 Text en Copyright © 2022 Zhou, Xiong, Chai, Huang, Tang, Zhang, Liu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zhou, Lie
Xiong, Jia-Yao
Chai, Yu-Qian
Huang, Lu
Tang, Zi-Yang
Zhang, Xin-Feng
Liu, Bo
Zhang, Jun-Tao
Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
title Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
title_full Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
title_fullStr Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
title_full_unstemmed Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
title_short Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
title_sort possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473681/
https://www.ncbi.nlm.nih.gov/pubmed/36117650
http://dx.doi.org/10.3389/fpsyt.2022.933704
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