Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection

COVID-19 is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate that human cardiac pericytes are permissive to SARS-CoV-2 infection in organoty...

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Detalles Bibliográficos
Autores principales: Brumback, Brittany D., Dmytrenko, Oleksandr, Robinson, Ashley N., Bailey, Adam L., Ma, Pan, Liu, Jing, Hicks, Stephanie C., Ng, Sherwin, Li, Gang, Zhang, David M., Lipovsky, Catherine E., Lin, Chieh-Yu, Diamond, Michael S., Lavine, Kory J., Rentschler, Stacey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Leading Edge Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473702/
https://www.ncbi.nlm.nih.gov/pubmed/36124009
http://dx.doi.org/10.1016/j.jacbts.2022.09.001
Descripción
Sumario:COVID-19 is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate that human cardiac pericytes are permissive to SARS-CoV-2 infection in organotypic slice and primary cell cultures. Viral entry into pericytes is mediated by endosomal proteases, and infection leads to up-regulation of inflammatory markers, vasoactive mediators, and nuclear factor kappa-B–dependent cell death. Furthermore, we present evidence of cardiac pericyte infection in COVID-19 myocarditis patients. These data demonstrate that human cardiac pericytes are susceptible to SARS-CoV-2 infection and suggest a role for pericyte infection in COVID-19.

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