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Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection
COVID-19 is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate that human cardiac pericytes are permissive to SARS-CoV-2 infection in organoty...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473702/ https://www.ncbi.nlm.nih.gov/pubmed/36124009 http://dx.doi.org/10.1016/j.jacbts.2022.09.001 |
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| author | Brumback, Brittany D. Dmytrenko, Oleksandr Robinson, Ashley N. Bailey, Adam L. Ma, Pan Liu, Jing Hicks, Stephanie C. Ng, Sherwin Li, Gang Zhang, David M. Lipovsky, Catherine E. Lin, Chieh-Yu Diamond, Michael S. Lavine, Kory J. Rentschler, Stacey L. |
| author_facet | Brumback, Brittany D. Dmytrenko, Oleksandr Robinson, Ashley N. Bailey, Adam L. Ma, Pan Liu, Jing Hicks, Stephanie C. Ng, Sherwin Li, Gang Zhang, David M. Lipovsky, Catherine E. Lin, Chieh-Yu Diamond, Michael S. Lavine, Kory J. Rentschler, Stacey L. |
| author_sort | Brumback, Brittany D. |
| collection | PubMed |
| description | COVID-19 is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate that human cardiac pericytes are permissive to SARS-CoV-2 infection in organotypic slice and primary cell cultures. Viral entry into pericytes is mediated by endosomal proteases, and infection leads to up-regulation of inflammatory markers, vasoactive mediators, and nuclear factor kappa-B–dependent cell death. Furthermore, we present evidence of cardiac pericyte infection in COVID-19 myocarditis patients. These data demonstrate that human cardiac pericytes are susceptible to SARS-CoV-2 infection and suggest a role for pericyte infection in COVID-19. |
| format | Online Article Text |
| id | pubmed-9473702 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94737022022-09-15 Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection Brumback, Brittany D. Dmytrenko, Oleksandr Robinson, Ashley N. Bailey, Adam L. Ma, Pan Liu, Jing Hicks, Stephanie C. Ng, Sherwin Li, Gang Zhang, David M. Lipovsky, Catherine E. Lin, Chieh-Yu Diamond, Michael S. Lavine, Kory J. Rentschler, Stacey L. JACC Basic Transl Sci Leading Edge Translational Research COVID-19 is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate that human cardiac pericytes are permissive to SARS-CoV-2 infection in organotypic slice and primary cell cultures. Viral entry into pericytes is mediated by endosomal proteases, and infection leads to up-regulation of inflammatory markers, vasoactive mediators, and nuclear factor kappa-B–dependent cell death. Furthermore, we present evidence of cardiac pericyte infection in COVID-19 myocarditis patients. These data demonstrate that human cardiac pericytes are susceptible to SARS-CoV-2 infection and suggest a role for pericyte infection in COVID-19. Elsevier 2022-09-14 /pmc/articles/PMC9473702/ /pubmed/36124009 http://dx.doi.org/10.1016/j.jacbts.2022.09.001 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Leading Edge Translational Research Brumback, Brittany D. Dmytrenko, Oleksandr Robinson, Ashley N. Bailey, Adam L. Ma, Pan Liu, Jing Hicks, Stephanie C. Ng, Sherwin Li, Gang Zhang, David M. Lipovsky, Catherine E. Lin, Chieh-Yu Diamond, Michael S. Lavine, Kory J. Rentschler, Stacey L. Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection |
| title | Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection |
| title_full | Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection |
| title_fullStr | Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection |
| title_full_unstemmed | Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection |
| title_short | Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection |
| title_sort | human cardiac pericytes are susceptible to sars-cov-2 infection |
| topic | Leading Edge Translational Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473702/ https://www.ncbi.nlm.nih.gov/pubmed/36124009 http://dx.doi.org/10.1016/j.jacbts.2022.09.001 |
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