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Integrated hepatitis B virus DNA maintains surface antigen production during antiviral treatment

The focus of hepatitis B functional cure, defined as sustained loss of hepatitis B virus (HBV) surface antigen (HBsAg) and HBV DNA from blood, is on eliminating or silencing the intranuclear template for HBV replication, covalently closed circular DNA (cccDNA). However, HBsAg also derives from HBV D...

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Detalles Bibliográficos
Autores principales:	Grudda, Tanner, Hwang, Hyon S., Taddese, Maraake, Quinn, Jeffrey, Sulkowski, Mark S., Sterling, Richard K., Balagopal, Ashwin, Thio, Chloe L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473722/ https://www.ncbi.nlm.nih.gov/pubmed/35797115 http://dx.doi.org/10.1172/JCI161818

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