Cargando…
Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system
Organ on a chip or microphysiological systems (MPSs) aim to resolve current challenges surrounding drug discovery and development resulting from an unrepresentative static cell culture or animal models that are traditionally used by generating a more physiologically relevant environment. Many differ...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473724/ https://www.ncbi.nlm.nih.gov/pubmed/36118260 http://dx.doi.org/10.1063/5.0100019 |
_version_ | 1784789564347383808 |
---|---|
author | Karra, Nikita Fernandes, Joao Swindle, Emily Jane Morgan, Hywel |
author_facet | Karra, Nikita Fernandes, Joao Swindle, Emily Jane Morgan, Hywel |
author_sort | Karra, Nikita |
collection | PubMed |
description | Organ on a chip or microphysiological systems (MPSs) aim to resolve current challenges surrounding drug discovery and development resulting from an unrepresentative static cell culture or animal models that are traditionally used by generating a more physiologically relevant environment. Many different airway MPSs have been developed that mimic alveolar or bronchial interfaces, but few methods for aerosol drug delivery at the air–liquid interface exist. This work demonstrates a compact Surface Acoustic Wave (SAW) drug delivery device that generates an aerosol of respirable size for delivery of compounds directly onto polarized or differentiated epithelial cell cultures within an airway barrier MPS and conventional static inserts. As proof of principle, the SAW drug delivery device was used to nebulize viral dsRNA analog poly I:C and steroids fluticasone and dexamethasone without disrupting their biological function. |
format | Online Article Text |
id | pubmed-9473724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-94737242022-09-15 Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system Karra, Nikita Fernandes, Joao Swindle, Emily Jane Morgan, Hywel Biomicrofluidics Regular Articles Organ on a chip or microphysiological systems (MPSs) aim to resolve current challenges surrounding drug discovery and development resulting from an unrepresentative static cell culture or animal models that are traditionally used by generating a more physiologically relevant environment. Many different airway MPSs have been developed that mimic alveolar or bronchial interfaces, but few methods for aerosol drug delivery at the air–liquid interface exist. This work demonstrates a compact Surface Acoustic Wave (SAW) drug delivery device that generates an aerosol of respirable size for delivery of compounds directly onto polarized or differentiated epithelial cell cultures within an airway barrier MPS and conventional static inserts. As proof of principle, the SAW drug delivery device was used to nebulize viral dsRNA analog poly I:C and steroids fluticasone and dexamethasone without disrupting their biological function. AIP Publishing LLC 2022-09-13 /pmc/articles/PMC9473724/ /pubmed/36118260 http://dx.doi.org/10.1063/5.0100019 Text en © 2022 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). Published open access through an agreement withJISC Collections128554 |
spellingShingle | Regular Articles Karra, Nikita Fernandes, Joao Swindle, Emily Jane Morgan, Hywel Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system |
title | Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system |
title_full | Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system |
title_fullStr | Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system |
title_full_unstemmed | Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system |
title_short | Integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system |
title_sort | integrating an aerosolized drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system |
topic | Regular Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9473724/ https://www.ncbi.nlm.nih.gov/pubmed/36118260 http://dx.doi.org/10.1063/5.0100019 |
work_keys_str_mv | AT karranikita integratinganaerosolizeddrugdeliverydevicewithconventionalstaticculturesandadynamicairwaybarriermicrophysiologicalsystem AT fernandesjoao integratinganaerosolizeddrugdeliverydevicewithconventionalstaticculturesandadynamicairwaybarriermicrophysiologicalsystem AT swindleemilyjane integratinganaerosolizeddrugdeliverydevicewithconventionalstaticculturesandadynamicairwaybarriermicrophysiologicalsystem AT morganhywel integratinganaerosolizeddrugdeliverydevicewithconventionalstaticculturesandadynamicairwaybarriermicrophysiologicalsystem |