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Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment
PURPOSE: Total intracranial volume (TIV) is often a nuisance covariate in MRI-based brain volumetry. This study compared two TIV adjustment methods with respect to their impact on z-scores in single subject analyses of regional brain volume estimates. METHODS: Brain parenchyma, hippocampus, thalamus...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474386/ https://www.ncbi.nlm.nih.gov/pubmed/35462574 http://dx.doi.org/10.1007/s00234-022-02961-6 |
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author | Opfer, Roland Krüger, Julia Spies, Lothar Kitzler, Hagen H. Schippling, Sven Buchert, Ralph |
author_facet | Opfer, Roland Krüger, Julia Spies, Lothar Kitzler, Hagen H. Schippling, Sven Buchert, Ralph |
author_sort | Opfer, Roland |
collection | PubMed |
description | PURPOSE: Total intracranial volume (TIV) is often a nuisance covariate in MRI-based brain volumetry. This study compared two TIV adjustment methods with respect to their impact on z-scores in single subject analyses of regional brain volume estimates. METHODS: Brain parenchyma, hippocampus, thalamus, and TIV were segmented in a normal database comprising 5059 T1w images. Regional volume estimates were adjusted for TIV using the residual method or the proportion method. Age was taken into account by regression with both methods. TIV- and age-adjusted regional volumes were transformed to z-scores and then compared between the two adjustment methods. Their impact on the detection of thalamus atrophy was tested in 127 patients with multiple sclerosis. RESULTS: The residual method removed the association with TIV in all regions. The proportion method resulted in a switch of the direction without relevant change of the strength of the association. The reduction of physiological between-subject variability was larger with the residual method than with the proportion method. The difference between z-scores obtained with the residual method versus the proportion method was strongly correlated with TIV. It was larger than one z-score point in 5% of the subjects. The area under the ROC curve of the TIV- and age-adjusted thalamus volume for identification of multiple sclerosis patients was larger with the residual method than with the proportion method (0.84 versus 0.79). CONCLUSION: The residual method should be preferred for TIV and age adjustments of T1w-MRI-based brain volume estimates in single subject analyses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00234-022-02961-6. |
format | Online Article Text |
id | pubmed-9474386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-94743862022-09-16 Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment Opfer, Roland Krüger, Julia Spies, Lothar Kitzler, Hagen H. Schippling, Sven Buchert, Ralph Neuroradiology Functional Neuroradiology PURPOSE: Total intracranial volume (TIV) is often a nuisance covariate in MRI-based brain volumetry. This study compared two TIV adjustment methods with respect to their impact on z-scores in single subject analyses of regional brain volume estimates. METHODS: Brain parenchyma, hippocampus, thalamus, and TIV were segmented in a normal database comprising 5059 T1w images. Regional volume estimates were adjusted for TIV using the residual method or the proportion method. Age was taken into account by regression with both methods. TIV- and age-adjusted regional volumes were transformed to z-scores and then compared between the two adjustment methods. Their impact on the detection of thalamus atrophy was tested in 127 patients with multiple sclerosis. RESULTS: The residual method removed the association with TIV in all regions. The proportion method resulted in a switch of the direction without relevant change of the strength of the association. The reduction of physiological between-subject variability was larger with the residual method than with the proportion method. The difference between z-scores obtained with the residual method versus the proportion method was strongly correlated with TIV. It was larger than one z-score point in 5% of the subjects. The area under the ROC curve of the TIV- and age-adjusted thalamus volume for identification of multiple sclerosis patients was larger with the residual method than with the proportion method (0.84 versus 0.79). CONCLUSION: The residual method should be preferred for TIV and age adjustments of T1w-MRI-based brain volume estimates in single subject analyses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00234-022-02961-6. Springer Berlin Heidelberg 2022-04-25 2022 /pmc/articles/PMC9474386/ /pubmed/35462574 http://dx.doi.org/10.1007/s00234-022-02961-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Functional Neuroradiology Opfer, Roland Krüger, Julia Spies, Lothar Kitzler, Hagen H. Schippling, Sven Buchert, Ralph Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment |
title | Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment |
title_full | Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment |
title_fullStr | Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment |
title_full_unstemmed | Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment |
title_short | Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment |
title_sort | single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment |
topic | Functional Neuroradiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474386/ https://www.ncbi.nlm.nih.gov/pubmed/35462574 http://dx.doi.org/10.1007/s00234-022-02961-6 |
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