Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several compounds with the ability to induce training effects...

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Detalles Bibliográficos
Autores principales: John, Sinu P., Singh, Anju, Sun, Jing, Pierre, Makheni Jean, Alsalih, Lulwah, Lipsey, Crystal, Traore, Ziann, Balcom-Luker, Shenavia, Bradfield, Clinton J., Song, Jian, Markowitz, Tovah E., Smelkinson, Margery, Ferrer, Marc, Fraser, Iain D.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474420/
https://www.ncbi.nlm.nih.gov/pubmed/36179680
http://dx.doi.org/10.1016/j.celrep.2022.111441

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