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The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results

PURPOSE: This study aimed at identifying gender differences in the hearing thresholds in a sample of patients with otosclerosis before and after surgery to understand the impact of female hormones on auditory thresholds. METHODS: This retrospective study analyzed 184 patients (123 women and 61 men)...

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Autores principales: Ricci, Giampietro, Gambacorta, Valeria, Lapenna, Ruggero, della Volpe, Antonio, La Mantia, Ignazio, Ralli, Massimo, Di Stadio, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474451/
https://www.ncbi.nlm.nih.gov/pubmed/35187596
http://dx.doi.org/10.1007/s00405-022-07295-w
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author Ricci, Giampietro
Gambacorta, Valeria
Lapenna, Ruggero
della Volpe, Antonio
La Mantia, Ignazio
Ralli, Massimo
Di Stadio, Arianna
author_facet Ricci, Giampietro
Gambacorta, Valeria
Lapenna, Ruggero
della Volpe, Antonio
La Mantia, Ignazio
Ralli, Massimo
Di Stadio, Arianna
author_sort Ricci, Giampietro
collection PubMed
description PURPOSE: This study aimed at identifying gender differences in the hearing thresholds in a sample of patients with otosclerosis before and after surgery to understand the impact of female hormones on auditory thresholds. METHODS: This retrospective study analyzed 184 patients (123 women and 61 men) affected by otosclerosis. All the patients were affected by conductive hearing loss and treated by stapedoplasty. Auditory thresholds at the baseline (T0) and one month after surgery (T30) were collected. Air and bone thresholds and Air Bone Gap (ABG) were compared between females and males using one-way ANOVA. RESULTS: Statistically significant differences were observed comparing the air threshold at T0 vs T30 both in women and men (p < 0.0001). No statistically significant differences were observed in the bone conduction thresholds before and after surgery. The comparison between females and males showed statistically significant differences both at T0 (p < 0.01) and T30 (p < 0.05) for air conduction thresholds and ABG at 4000 Hz. CONCLUSION: Although stapedoplasty reduced the difference between females and males in the air conduction thresholds and ABG, women showed better recovery of their middle ear function with better auditory thresholds and ABG. The female hormones might positively impact the ligaments of the incudostapedial joint improving chain flexibility. This benefit might explain the statistically significant difference observed in women at 4000 Hz before and after surgery.
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spelling pubmed-94744512022-09-16 The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results Ricci, Giampietro Gambacorta, Valeria Lapenna, Ruggero della Volpe, Antonio La Mantia, Ignazio Ralli, Massimo Di Stadio, Arianna Eur Arch Otorhinolaryngol Otology PURPOSE: This study aimed at identifying gender differences in the hearing thresholds in a sample of patients with otosclerosis before and after surgery to understand the impact of female hormones on auditory thresholds. METHODS: This retrospective study analyzed 184 patients (123 women and 61 men) affected by otosclerosis. All the patients were affected by conductive hearing loss and treated by stapedoplasty. Auditory thresholds at the baseline (T0) and one month after surgery (T30) were collected. Air and bone thresholds and Air Bone Gap (ABG) were compared between females and males using one-way ANOVA. RESULTS: Statistically significant differences were observed comparing the air threshold at T0 vs T30 both in women and men (p < 0.0001). No statistically significant differences were observed in the bone conduction thresholds before and after surgery. The comparison between females and males showed statistically significant differences both at T0 (p < 0.01) and T30 (p < 0.05) for air conduction thresholds and ABG at 4000 Hz. CONCLUSION: Although stapedoplasty reduced the difference between females and males in the air conduction thresholds and ABG, women showed better recovery of their middle ear function with better auditory thresholds and ABG. The female hormones might positively impact the ligaments of the incudostapedial joint improving chain flexibility. This benefit might explain the statistically significant difference observed in women at 4000 Hz before and after surgery. Springer Berlin Heidelberg 2022-02-21 2022 /pmc/articles/PMC9474451/ /pubmed/35187596 http://dx.doi.org/10.1007/s00405-022-07295-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Otology
Ricci, Giampietro
Gambacorta, Valeria
Lapenna, Ruggero
della Volpe, Antonio
La Mantia, Ignazio
Ralli, Massimo
Di Stadio, Arianna
The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results
title The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results
title_full The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results
title_fullStr The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results
title_full_unstemmed The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results
title_short The effect of female hormone in otosclerosis. A comparative study and speculation about their effect on the ossicular chain based on the clinical results
title_sort effect of female hormone in otosclerosis. a comparative study and speculation about their effect on the ossicular chain based on the clinical results
topic Otology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474451/
https://www.ncbi.nlm.nih.gov/pubmed/35187596
http://dx.doi.org/10.1007/s00405-022-07295-w
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