Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation

Xanthone-containing natural products display diverse pharmacological properties. The biosynthetic mechanisms of the xanthone formation have not been well documented. Here we show that the flavoprotein monooxygenase FlsO1 in the biosynthesis of fluostatins not only functionally compensates for the mo...

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Detalles Bibliográficos
Autores principales: Yang, Chunfang, Zhang, Liping, Zhang, Wenjun, Huang, Chunshuai, Zhu, Yiguang, Jiang, Xiaodong, Liu, Wei, Zhao, Mengran, De, Bidhan Chandra, Zhang, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474520/
https://www.ncbi.nlm.nih.gov/pubmed/36104338
http://dx.doi.org/10.1038/s41467-022-33131-0

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