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The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression

Circular RNA (circRNA) is characterized by a specific covalently closed ring structure. The back-splicing of precursor mRNA is the main way of circRNA generation, and various cis/trans-acting elements are involved in regulating the process. circRNAs exhibit multiple biological functions, including s...

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Autores principales: Yuan, Yuan, Zhang, Xiaojing, Fan, Xinmin, Peng, Yin, Jin, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474543/
https://www.ncbi.nlm.nih.gov/pubmed/36104321
http://dx.doi.org/10.1038/s41420-022-01172-5
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author Yuan, Yuan
Zhang, Xiaojing
Fan, Xinmin
Peng, Yin
Jin, Zhe
author_facet Yuan, Yuan
Zhang, Xiaojing
Fan, Xinmin
Peng, Yin
Jin, Zhe
author_sort Yuan, Yuan
collection PubMed
description Circular RNA (circRNA) is characterized by a specific covalently closed ring structure. The back-splicing of precursor mRNA is the main way of circRNA generation, and various cis/trans-acting elements are involved in regulating the process. circRNAs exhibit multiple biological functions, including serving as sponges of microRNAs, interacting with proteins to regulate their stabilities and abilities, and acting as templates for protein translation. Autophagy participates in many physiological and pathological processes, especially it plays a vital role in tumorigenesis and carcinoma progression. Increasing numbers of evidences have revealed that circRNAs are implicated in regulating autophagy during tumor development. Until now, the roles of autophagy-associated circRNAs in carcinoma progression and their molecular mechanisms remain unclear. Here, the emerging regulatory roles and mechanisms of circRNAs in autophagy were summarized. Furtherly, the effects of autophagy-associated circRNAs on cancer development were described. We also prospected the potential of autophagy-associated circRNAs as novel therapeutic targets of tumors and as biomarkers for cancer diagnosis and prognosis.
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spelling pubmed-94745432022-09-16 The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression Yuan, Yuan Zhang, Xiaojing Fan, Xinmin Peng, Yin Jin, Zhe Cell Death Discov Review Article Circular RNA (circRNA) is characterized by a specific covalently closed ring structure. The back-splicing of precursor mRNA is the main way of circRNA generation, and various cis/trans-acting elements are involved in regulating the process. circRNAs exhibit multiple biological functions, including serving as sponges of microRNAs, interacting with proteins to regulate their stabilities and abilities, and acting as templates for protein translation. Autophagy participates in many physiological and pathological processes, especially it plays a vital role in tumorigenesis and carcinoma progression. Increasing numbers of evidences have revealed that circRNAs are implicated in regulating autophagy during tumor development. Until now, the roles of autophagy-associated circRNAs in carcinoma progression and their molecular mechanisms remain unclear. Here, the emerging regulatory roles and mechanisms of circRNAs in autophagy were summarized. Furtherly, the effects of autophagy-associated circRNAs on cancer development were described. We also prospected the potential of autophagy-associated circRNAs as novel therapeutic targets of tumors and as biomarkers for cancer diagnosis and prognosis. Nature Publishing Group UK 2022-09-14 /pmc/articles/PMC9474543/ /pubmed/36104321 http://dx.doi.org/10.1038/s41420-022-01172-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Yuan, Yuan
Zhang, Xiaojing
Fan, Xinmin
Peng, Yin
Jin, Zhe
The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
title The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
title_full The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
title_fullStr The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
title_full_unstemmed The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
title_short The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
title_sort emerging roles of circular rna-mediated autophagy in tumorigenesis and cancer progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474543/
https://www.ncbi.nlm.nih.gov/pubmed/36104321
http://dx.doi.org/10.1038/s41420-022-01172-5
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