SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

OBJECTIVE: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that SORLA transcripts are also found in beta cells of p...

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Detalles Bibliográficos
Autores principales: Shih, Alexis Z.L., Chen, Yi-Chun, Speckmann, Thilo, Søndergaard, Esben, Schürmann, Annette, Verchere, C. Bruce, Willnow, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474563/
https://www.ncbi.nlm.nih.gov/pubmed/36055578
http://dx.doi.org/10.1016/j.molmet.2022.101585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474563/
https://www.ncbi.nlm.nih.gov/pubmed/36055578
http://dx.doi.org/10.1016/j.molmet.2022.101585

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