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Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study

Background: Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS hold the potential to inform a selection of stimulation parameters. In recent years, the focus has shifted towards DBS-induced firing in myelinated axons, deeme...

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Autores principales: Butenko, Konstantin, Li, Ningfei, Neudorfer, Clemens, Roediger, Jan, Horn, Andreas, Wenzel, Gregor R., Eldebakey, Hazem, Kühn, Andrea A., Reich, Martin M., Volkmann, Jens, Rienen, Ursula van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474565/
https://www.ncbi.nlm.nih.gov/pubmed/36099807
http://dx.doi.org/10.1016/j.nicl.2022.103185
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author Butenko, Konstantin
Li, Ningfei
Neudorfer, Clemens
Roediger, Jan
Horn, Andreas
Wenzel, Gregor R.
Eldebakey, Hazem
Kühn, Andrea A.
Reich, Martin M.
Volkmann, Jens
Rienen, Ursula van
author_facet Butenko, Konstantin
Li, Ningfei
Neudorfer, Clemens
Roediger, Jan
Horn, Andreas
Wenzel, Gregor R.
Eldebakey, Hazem
Kühn, Andrea A.
Reich, Martin M.
Volkmann, Jens
Rienen, Ursula van
author_sort Butenko, Konstantin
collection PubMed
description Background: Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS hold the potential to inform a selection of stimulation parameters. In recent years, the focus has shifted towards DBS-induced firing in myelinated axons, deemed particularly relevant for the external modulation of neural activity. Objective: The aim of this project was to investigate correlations between patient-specific pathway activation profiles and clinical motor improvement. Methods: We used the concept of pathway activation modeling, which incorporates advanced volume conductor models and anatomically authentic fiber trajectories to estimate DBS-induced action potential initiation in anatomically plausible pathways that traverse in close proximity to targeted nuclei. We applied the method on two retrospective datasets of DBS patients, whose clinical improvement had been evaluated according to the motor part of the Unified Parkinson’s Disease Rating Scale. Based on differences in outcome and activation levels for intrapatient DBS protocols in a training cohort, we derived a pathway activation profile that theoretically induces a complete alleviation of symptoms described by UPDRS-III. The profile was further enhanced by analyzing the importance of matching activation levels for individual pathways. Results: The obtained profile emphasized the importance of activation in pathways descending from the motor-relevant cortical regions as well as the pallidothalamic pathways. The degree of similarity of patient-specific profiles to the optimal profile significantly correlated with clinical motor improvement in a test cohort. Conclusion: Pathway activation modeling has a translational utility in the context of motor symptom alleviation in Parkinson’s patients treated with DBS.
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spelling pubmed-94745652022-09-16 Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study Butenko, Konstantin Li, Ningfei Neudorfer, Clemens Roediger, Jan Horn, Andreas Wenzel, Gregor R. Eldebakey, Hazem Kühn, Andrea A. Reich, Martin M. Volkmann, Jens Rienen, Ursula van Neuroimage Clin Regular Article Background: Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS hold the potential to inform a selection of stimulation parameters. In recent years, the focus has shifted towards DBS-induced firing in myelinated axons, deemed particularly relevant for the external modulation of neural activity. Objective: The aim of this project was to investigate correlations between patient-specific pathway activation profiles and clinical motor improvement. Methods: We used the concept of pathway activation modeling, which incorporates advanced volume conductor models and anatomically authentic fiber trajectories to estimate DBS-induced action potential initiation in anatomically plausible pathways that traverse in close proximity to targeted nuclei. We applied the method on two retrospective datasets of DBS patients, whose clinical improvement had been evaluated according to the motor part of the Unified Parkinson’s Disease Rating Scale. Based on differences in outcome and activation levels for intrapatient DBS protocols in a training cohort, we derived a pathway activation profile that theoretically induces a complete alleviation of symptoms described by UPDRS-III. The profile was further enhanced by analyzing the importance of matching activation levels for individual pathways. Results: The obtained profile emphasized the importance of activation in pathways descending from the motor-relevant cortical regions as well as the pallidothalamic pathways. The degree of similarity of patient-specific profiles to the optimal profile significantly correlated with clinical motor improvement in a test cohort. Conclusion: Pathway activation modeling has a translational utility in the context of motor symptom alleviation in Parkinson’s patients treated with DBS. Elsevier 2022-09-07 /pmc/articles/PMC9474565/ /pubmed/36099807 http://dx.doi.org/10.1016/j.nicl.2022.103185 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Butenko, Konstantin
Li, Ningfei
Neudorfer, Clemens
Roediger, Jan
Horn, Andreas
Wenzel, Gregor R.
Eldebakey, Hazem
Kühn, Andrea A.
Reich, Martin M.
Volkmann, Jens
Rienen, Ursula van
Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study
title Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study
title_full Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study
title_fullStr Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study
title_full_unstemmed Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study
title_short Linking profiles of pathway activation with clinical motor improvements – A retrospective computational study
title_sort linking profiles of pathway activation with clinical motor improvements – a retrospective computational study
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474565/
https://www.ncbi.nlm.nih.gov/pubmed/36099807
http://dx.doi.org/10.1016/j.nicl.2022.103185
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