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Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques

PURPOSE: To fully automate CT‐based cervical cancer radiotherapy by automating contouring and planning for three different treatment techniques. METHODS: We automated three different radiotherapy planning techniques for locally advanced cervical cancer: 2D 4‐field‐box (4‐field‐box), 3D conformal rad...

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Autores principales: Rhee, Dong Joo, Jhingran, Anuja, Huang, Kai, Netherton, Tucker J., Fakie, Nazia, White, Ingrid, Sherriff, Alicia, Cardenas, Carlos E., Zhang, Lifei, Prajapati, Surendra, Kry, Stephen F., Beadle, Beth M., Shaw, William, O'Reilly, Frederika, Parkes, Jeannette, Burger, Hester, Trauernicht, Chris, Simonds, Hannah, Court, Laurence E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474595/
https://www.ncbi.nlm.nih.gov/pubmed/35866442
http://dx.doi.org/10.1002/mp.15868
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author Rhee, Dong Joo
Jhingran, Anuja
Huang, Kai
Netherton, Tucker J.
Fakie, Nazia
White, Ingrid
Sherriff, Alicia
Cardenas, Carlos E.
Zhang, Lifei
Prajapati, Surendra
Kry, Stephen F.
Beadle, Beth M.
Shaw, William
O'Reilly, Frederika
Parkes, Jeannette
Burger, Hester
Trauernicht, Chris
Simonds, Hannah
Court, Laurence E.
author_facet Rhee, Dong Joo
Jhingran, Anuja
Huang, Kai
Netherton, Tucker J.
Fakie, Nazia
White, Ingrid
Sherriff, Alicia
Cardenas, Carlos E.
Zhang, Lifei
Prajapati, Surendra
Kry, Stephen F.
Beadle, Beth M.
Shaw, William
O'Reilly, Frederika
Parkes, Jeannette
Burger, Hester
Trauernicht, Chris
Simonds, Hannah
Court, Laurence E.
author_sort Rhee, Dong Joo
collection PubMed
description PURPOSE: To fully automate CT‐based cervical cancer radiotherapy by automating contouring and planning for three different treatment techniques. METHODS: We automated three different radiotherapy planning techniques for locally advanced cervical cancer: 2D 4‐field‐box (4‐field‐box), 3D conformal radiotherapy (3D‐CRT), and volumetric modulated arc therapy (VMAT). These auto‐planning algorithms were combined with a previously developed auto‐contouring system. To improve the quality of the 4‐field‐box and 3D‐CRT plans, we used an in‐house, field‐in‐field (FIF) automation program. Thirty‐five plans were generated for each technique on CT scans from multiple institutions and evaluated by five experienced radiation oncologists from three different countries. Every plan was reviewed by two of the five radiation oncologists and scored using a 5‐point Likert scale. RESULTS: Overall, 87%, 99%, and 94% of the automatically generated plans were found to be clinically acceptable without modification for the 4‐field‐box, 3D‐CRT, and VMAT plans, respectively. Some customizations of the FIF configuration were necessary on the basis of radiation oncologist preference. Additionally, in some cases, it was necessary to renormalize the plan after it was generated to satisfy radiation oncologist preference. CONCLUSION: Approximately, 90% of the automatically generated plans were clinically acceptable for all three planning techniques. This fully automated planning system has been implemented into the radiation planning assistant for further testing in resource‐constrained radiotherapy departments in low‐ and middle‐income countries.
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spelling pubmed-94745952022-10-14 Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques Rhee, Dong Joo Jhingran, Anuja Huang, Kai Netherton, Tucker J. Fakie, Nazia White, Ingrid Sherriff, Alicia Cardenas, Carlos E. Zhang, Lifei Prajapati, Surendra Kry, Stephen F. Beadle, Beth M. Shaw, William O'Reilly, Frederika Parkes, Jeannette Burger, Hester Trauernicht, Chris Simonds, Hannah Court, Laurence E. Med Phys THERAPEUTIC INTERVENTIONS PURPOSE: To fully automate CT‐based cervical cancer radiotherapy by automating contouring and planning for three different treatment techniques. METHODS: We automated three different radiotherapy planning techniques for locally advanced cervical cancer: 2D 4‐field‐box (4‐field‐box), 3D conformal radiotherapy (3D‐CRT), and volumetric modulated arc therapy (VMAT). These auto‐planning algorithms were combined with a previously developed auto‐contouring system. To improve the quality of the 4‐field‐box and 3D‐CRT plans, we used an in‐house, field‐in‐field (FIF) automation program. Thirty‐five plans were generated for each technique on CT scans from multiple institutions and evaluated by five experienced radiation oncologists from three different countries. Every plan was reviewed by two of the five radiation oncologists and scored using a 5‐point Likert scale. RESULTS: Overall, 87%, 99%, and 94% of the automatically generated plans were found to be clinically acceptable without modification for the 4‐field‐box, 3D‐CRT, and VMAT plans, respectively. Some customizations of the FIF configuration were necessary on the basis of radiation oncologist preference. Additionally, in some cases, it was necessary to renormalize the plan after it was generated to satisfy radiation oncologist preference. CONCLUSION: Approximately, 90% of the automatically generated plans were clinically acceptable for all three planning techniques. This fully automated planning system has been implemented into the radiation planning assistant for further testing in resource‐constrained radiotherapy departments in low‐ and middle‐income countries. John Wiley and Sons Inc. 2022-07-26 2022-09 /pmc/articles/PMC9474595/ /pubmed/35866442 http://dx.doi.org/10.1002/mp.15868 Text en © 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle THERAPEUTIC INTERVENTIONS
Rhee, Dong Joo
Jhingran, Anuja
Huang, Kai
Netherton, Tucker J.
Fakie, Nazia
White, Ingrid
Sherriff, Alicia
Cardenas, Carlos E.
Zhang, Lifei
Prajapati, Surendra
Kry, Stephen F.
Beadle, Beth M.
Shaw, William
O'Reilly, Frederika
Parkes, Jeannette
Burger, Hester
Trauernicht, Chris
Simonds, Hannah
Court, Laurence E.
Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques
title Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques
title_full Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques
title_fullStr Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques
title_full_unstemmed Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques
title_short Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques
title_sort clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques
topic THERAPEUTIC INTERVENTIONS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474595/
https://www.ncbi.nlm.nih.gov/pubmed/35866442
http://dx.doi.org/10.1002/mp.15868
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