Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca(2+)/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability

CaMKIIα plays a fundamental role in learning and memory and is a key determinant of synaptic plasticity. Its kinase activity is regulated by the binding of Ca(2+)/CaM and by autophosphorylation that operates in an activity-dependent manner. Though many mutations in CAMK2A were linked to a variety of...

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Detalles Bibliográficos
Autores principales: Fujii, Hajime, Kidokoro, Hiroyuki, Kondo, Yayoi, Kawaguchi, Masahiro, Horigane, Shin-ichiro, Natsume, Jun, Takemoto-Kimura, Sayaka, Bito, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474683/
https://www.ncbi.nlm.nih.gov/pubmed/36117912
http://dx.doi.org/10.3389/fnmol.2022.970031

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