PARP targeted Auger emitter therapy with [(125)I]PARPi-01 for triple-negative breast cancer

BACKGROUND: Triple-negative breast cancer (TNBC) lacks biomarkers for targeted therapy. Auger emitters display the best therapeutic effect, if delivered directly into the nucleus proximal to DNA. The nuclear protein Poly (ADP-ribose)-Polymerase 1 (PARP1) is a suitable target against which few inhibi...

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Detalles Bibliográficos
Autores principales: Ambur Sankaranarayanan, Ramya, Florea, Alexandru, Allekotte, Susanne, Vogg, Andreas T. J., Maurer, Jochen, Schäfer, Laura, Bolm, Carsten, Terhorst, Steven, Classen, Arno, Bauwens, Matthias, Morgenroth, Agnieszka, Mottaghy, Felix M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474773/
https://www.ncbi.nlm.nih.gov/pubmed/36104637
http://dx.doi.org/10.1186/s13550-022-00932-9

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