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Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia

The nature and severity of mitral/tufted (M/T) cells reactions to odorants presented in anesthesia depend on various factors, and, above all, the nature and concentration of the odor, anesthesia, and the functional state of the olfactory bulb (OB). Compared to wakefulness, under anesthesia, the inte...

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Autores principales: Kiroy, V.N., Kosenko, P.O., Smolikov, A.B., Saevskiy, A.I., Aslanyan, E.V., Shaposhnikov, P.D., Rebrov, Yu.A., Arsenyev, F.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474852/
https://www.ncbi.nlm.nih.gov/pubmed/36117854
http://dx.doi.org/10.1016/j.ibneur.2022.09.002
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author Kiroy, V.N.
Kosenko, P.O.
Smolikov, A.B.
Saevskiy, A.I.
Aslanyan, E.V.
Shaposhnikov, P.D.
Rebrov, Yu.A.
Arsenyev, F.V.
author_facet Kiroy, V.N.
Kosenko, P.O.
Smolikov, A.B.
Saevskiy, A.I.
Aslanyan, E.V.
Shaposhnikov, P.D.
Rebrov, Yu.A.
Arsenyev, F.V.
author_sort Kiroy, V.N.
collection PubMed
description The nature and severity of mitral/tufted (M/T) cells reactions to odorants presented in anesthesia depend on various factors, and, above all, the nature and concentration of the odor, anesthesia, and the functional state of the olfactory bulb (OB). Compared to wakefulness, under anesthesia, the intensity of OB M/T cells responses to the odorants presented increases. However, the influence of anesthesia dynamics on the intensity of such responses has not been studied. To address this problem in rats, the activity of M/T cells and the local field potentials (LFP) in OB were recorded in the course of xylazine-tiletamine-zolazepam (XTZ) anesthesia. It has been shown that in the course of the anesthesia, the average frequency of background and odorant-induced single-unit activity of M/T cells increases, while the dominant frequency value of LFP in the gamma frequency range (90–170 Hz), on the contrary, decreases. The observed effects are assumed to be associated with changes in the functional state of the OB and systems for processing olfactory information in anesthesia.
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spelling pubmed-94748522022-09-16 Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia Kiroy, V.N. Kosenko, P.O. Smolikov, A.B. Saevskiy, A.I. Aslanyan, E.V. Shaposhnikov, P.D. Rebrov, Yu.A. Arsenyev, F.V. IBRO Neurosci Rep Research Paper The nature and severity of mitral/tufted (M/T) cells reactions to odorants presented in anesthesia depend on various factors, and, above all, the nature and concentration of the odor, anesthesia, and the functional state of the olfactory bulb (OB). Compared to wakefulness, under anesthesia, the intensity of OB M/T cells responses to the odorants presented increases. However, the influence of anesthesia dynamics on the intensity of such responses has not been studied. To address this problem in rats, the activity of M/T cells and the local field potentials (LFP) in OB were recorded in the course of xylazine-tiletamine-zolazepam (XTZ) anesthesia. It has been shown that in the course of the anesthesia, the average frequency of background and odorant-induced single-unit activity of M/T cells increases, while the dominant frequency value of LFP in the gamma frequency range (90–170 Hz), on the contrary, decreases. The observed effects are assumed to be associated with changes in the functional state of the OB and systems for processing olfactory information in anesthesia. Elsevier 2022-09-06 /pmc/articles/PMC9474852/ /pubmed/36117854 http://dx.doi.org/10.1016/j.ibneur.2022.09.002 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Kiroy, V.N.
Kosenko, P.O.
Smolikov, A.B.
Saevskiy, A.I.
Aslanyan, E.V.
Shaposhnikov, P.D.
Rebrov, Yu.A.
Arsenyev, F.V.
Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia
title Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia
title_full Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia
title_fullStr Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia
title_full_unstemmed Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia
title_short Changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia
title_sort changes in spontaneous and odorant-induced single-unit activity of mitral/tufted neurons of the rat olfactory bulb during xylazine-tiletamine-zolazepam anesthesia
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474852/
https://www.ncbi.nlm.nih.gov/pubmed/36117854
http://dx.doi.org/10.1016/j.ibneur.2022.09.002
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