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Structural basis for APE1 processing DNA damage in the nucleosome

Genomic DNA is continually exposed to endogenous and exogenous factors that promote DNA damage. Eukaryotic genomic DNA is packaged into nucleosomes, which present a barrier to accessing and effectively repairing DNA damage. The mechanisms by which DNA repair proteins overcome this barrier to repair...

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Detalles Bibliográficos
Autores principales:	Weaver, Tyler M., Hoitsma, Nicole M., Spencer, Jonah J., Gakhar, Lokesh, Schnicker, Nicholas J., Freudenthal, Bret D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474862/ https://www.ncbi.nlm.nih.gov/pubmed/36104361 http://dx.doi.org/10.1038/s41467-022-33057-7

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