A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors

Although there have been studies correlating DYRK2 with a number of human cancers, there has been no pan-cancer analysis. Therefore, through the TCGA database, we conducted a related study on the expression of DYRK2 in cancers.The expression of DYRK2 is obviously increased in some cancers, while the...

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Autores principales: Qiu, Xinyue, Shen, Cheng, Zhao, Wenjing, Zhang, Xunlei, Zhao, Dakun, Wu, Xuming, Yang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474874/
https://www.ncbi.nlm.nih.gov/pubmed/36104345
http://dx.doi.org/10.1038/s41598-022-19087-7
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author Qiu, Xinyue
Shen, Cheng
Zhao, Wenjing
Zhang, Xunlei
Zhao, Dakun
Wu, Xuming
Yang, Lei
author_facet Qiu, Xinyue
Shen, Cheng
Zhao, Wenjing
Zhang, Xunlei
Zhao, Dakun
Wu, Xuming
Yang, Lei
author_sort Qiu, Xinyue
collection PubMed
description Although there have been studies correlating DYRK2 with a number of human cancers, there has been no pan-cancer analysis. Therefore, through the TCGA database, we conducted a related study on the expression of DYRK2 in cancers.The expression of DYRK2 is obviously increased in some cancers, while the opposite is true in others, and there is a clear association between its expression and the prognosis of cancer patients.The mutation of DYRK2 is also significantly correlated with patients’ prognosis in certain human tumors. In addition, phosphorylation and methylation levels of DYRK2 are different between tumor tissues and adjacent normal tissues in various tumors. In the tumour microenvironment, the expression of DYRK2 correlates with cancer-associated fibroblast infiltration, such as BLCA or HNSC. In order to fully understand the role of DYRK2 in different tumors, we conducted a pan-cancer analysis.
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spelling pubmed-94748742022-09-16 A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors Qiu, Xinyue Shen, Cheng Zhao, Wenjing Zhang, Xunlei Zhao, Dakun Wu, Xuming Yang, Lei Sci Rep Article Although there have been studies correlating DYRK2 with a number of human cancers, there has been no pan-cancer analysis. Therefore, through the TCGA database, we conducted a related study on the expression of DYRK2 in cancers.The expression of DYRK2 is obviously increased in some cancers, while the opposite is true in others, and there is a clear association between its expression and the prognosis of cancer patients.The mutation of DYRK2 is also significantly correlated with patients’ prognosis in certain human tumors. In addition, phosphorylation and methylation levels of DYRK2 are different between tumor tissues and adjacent normal tissues in various tumors. In the tumour microenvironment, the expression of DYRK2 correlates with cancer-associated fibroblast infiltration, such as BLCA or HNSC. In order to fully understand the role of DYRK2 in different tumors, we conducted a pan-cancer analysis. Nature Publishing Group UK 2022-09-14 /pmc/articles/PMC9474874/ /pubmed/36104345 http://dx.doi.org/10.1038/s41598-022-19087-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qiu, Xinyue
Shen, Cheng
Zhao, Wenjing
Zhang, Xunlei
Zhao, Dakun
Wu, Xuming
Yang, Lei
A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors
title A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors
title_full A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors
title_fullStr A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors
title_full_unstemmed A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors
title_short A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors
title_sort pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (y)-phosphorylation- regulated kinase 2 (dyrk2) in human tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474874/
https://www.ncbi.nlm.nih.gov/pubmed/36104345
http://dx.doi.org/10.1038/s41598-022-19087-7
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