Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1-methyl-nicotinamide (MNA). Overexpression of NNMT and the presence of the active metabolite MNA is associated with a number of d...

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Detalles Bibliográficos
Autores principales: Ruf, Sven, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Hallur, Mahanandeesha S., Rani, Shilpa, Kristam, Rajendra, Swaminathan, Srinivasan, Zope, Bharat Ravindra, Gondrala, Pavan Kumar, Swamy, Indu, Putta, V. P. Rama Kishore, Kandan, Saravanan, Zech, Gernot, Schreuder, Herman, Rudolph, Christine, Elvert, Ralf, Czech, Joerg, Birudukota, Swarnakumari, Siddiqui, M. Amir, Anand, Niranjan Naranapura, Mane, Vishal Subhash, Dittakavi, Sreekanth, Suresh, Juluri, Gosu, Ramachandraiah, Ramesh, Mullangi, Yura, Takeshi, Dhakshinamoorthy, Saravanakumar, Kannt, Aimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474883/
https://www.ncbi.nlm.nih.gov/pubmed/36104373
http://dx.doi.org/10.1038/s41598-022-19634-2

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