Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes

BACKGROUND: In vitro, animal model and clinical evidence suggests that tuberculosis is not a monomorphic disease, and that host response to tuberculosis is protean with multiple distinct molecular pathways and pathologies (endotypes). We applied unbiased clustering to identify separate tuberculosis...

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Detalles Bibliográficos
Autores principales: DiNardo, Andrew R., Gandhi, Tanmay, Heyckendorf, Jan, Grimm, Sandra L., Rajapakshe, Kimal, Nishiguchi, Tomoki, Reimann, Maja, Kirchner, H. Lester, Kahari, Jaqueline, Dlamini, Qiniso, Lange, Christoph, Goldmann, Torsten, Marwitz, Sebastian, Abhimanyu, Cirillo, Jeffrey D., Kaufmann, Stefan H.E., Netea, Mihai G., van Crevel, Reinout, Mandalakas, Anna M., Coarfa, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474892/
https://www.ncbi.nlm.nih.gov/pubmed/35169026
http://dx.doi.org/10.1183/13993003.02263-2021

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