Cargando…

The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathology

The Spike glycoprotein of SARS-CoV-2, the virus responsible for coronavirus disease 2019, binds to its ACE2 receptor for internalization in the host cells. Elderly individuals or those with subjacent disorders, such as obesity and diabetes, are more susceptible to COVID-19 severity. Additionally, se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duarte, Tâmie, Silva, Mônica de Medeiros, Michelotti, Paula, Barbosa, Nilda Berenice de Vargas, Feltes, Bruno César, Dorn, Márcio, Rocha, João Batista Teixeira da, Dalla Corte, Cristiane Lenz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474972/ https://www.ncbi.nlm.nih.gov/pubmed/36116726 http://dx.doi.org/10.1016/j.bbadis.2022.166551

Ejemplares similares

Characterizing the Protein Isoforms of foraging (for), the PKGI Ortholog in Drosophila melanogaster
por: Vasquez, Oscar E., et al.
Publicado: (2023)

Editorial: Computational and integrative approaches for developmental biology and molecular evolution
por: Feltes, Bruno César, et al.
Publicado: (2023)

Analysis of SARS-CoV Receptor Activity of ACE2 Orthologs
por: Olivieri, Emily R., et al.
Publicado: (2006)

Virtual Screening of Acetylcholinesterase Inhibitors Using the Lipinski's Rule of Five and ZINC Databank
por: Nogara, Pablo Andrei, et al.
Publicado: (2015)

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2
por: Mou, Huihui, et al.
Publicado: (2021)

Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2
por: Mou, Huihui, et al.
Publicado: (2020)

Fermitins, the Orthologs of Mammalian Kindlins, Regulate the Development of a Functional Cardiac Syncytium in Drosophila melanogaster
por: Catterson, James H., et al.
Publicado: (2013)

Drosophila melanogaster Mutated in its GBA1b Ortholog Recapitulates Neuronopathic Gaucher Disease
por: Cabasso, Or, et al.
Publicado: (2019)

The Drosophila melanogaster Ortholog of RFWD3 Functions Independently of RAD51 During DNA Repair
por: Carvajal-Garcia, Juan, et al.
Publicado: (2020)

Multi-Approach Bioinformatics Analysis of Curated Omics Data Provides a Gene Expression Panorama for Multiple Cancer Types
por: Feltes, Bruno César, et al.
Publicado: (2020)

SARS-CoV-2 and Three Related Coronaviruses Utilize Multiple ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-Ig
por: Li, Yujun, et al.
Publicado: (2020)

Biological effects of the frequent application of a copper-containing fungicide on the fruit fly Drosophila melanogaster
por: Zamberlan, Daniele, et al.
Publicado: (2023)

Twenty-seven ZAD-ZNF genes of Drosophila melanogaster are orthologous to the embryo polarity determining mosquito gene cucoid
por: Li, Muzi, et al.
Publicado: (2023)

The Quest for Orthologs orthology benchmark service in 2022
por: Nevers, Yannis, et al.
Publicado: (2022)

The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster
por: Salim, Safa, et al.
Publicado: (2023)

Effect of Syzygium cumini and Bauhinia forficata aqueous-leaf extracts on oxidative and mitochondrial parameters in vitro
por: Ecker, Assis, et al.
Publicado: (2015)

Simultaneous exposure to vinylcyclohexene and methylmercury in Drosophila melanogaster: biochemical and molecular analyses
por: Piccoli, Bruna Candia, et al.
Publicado: (2019)

Feature selection reveal peripheral blood parameter's changes between COVID-19 infections patients from Brazil and Ecuador
por: Feltes, Bruno César, et al.
Publicado: (2022)

Assessment of orthologous splicing isoforms in human and mouse orthologous genes
por: Zambelli, Federico, et al.
Publicado: (2010)

Inferring Hierarchical Orthologous Groups from Orthologous Gene Pairs
por: Altenhoff, Adrian M., et al.
Publicado: (2013)

Ortholog-Finder: A Tool for Constructing an Ortholog Data Set
por: Horiike, Tokumasa, et al.
Publicado: (2016)

The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction
por: Stamboulian, Moses, et al.
Publicado: (2020)

Comparison of machine learning techniques to handle imbalanced COVID-19 CBC datasets
por: Dorn, Marcio, et al.
Publicado: (2021)

Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice
por: da Luz, Sônia Cristina Almeida, et al.
Publicado: (2015)

Ebselen and Diphenyl Diselenide Inhibit SARS-CoV-2 Replication at Non-Toxic Concentrations to Human Cell Lines
por: Wildner, Guilherme, et al.
Publicado: (2023)

Antioxidant and antiulcer potential of aqueous leaf extract of Kigelia africana against ethanol-induced ulcer in rats
por: dos Santos, Matheus M, et al.
Publicado: (2014)

On the consistency of orthology relationships
por: Jones, Mark, et al.
Publicado: (2016)

Gene-oriented ortholog database: a functional comparison platform for orthologous loci
por: Ho, Meng-Ru, et al.
Publicado: (2010)

JustOrthologs: a fast, accurate and user-friendly ortholog identification algorithm
por: Miller, Justin B, et al.
Publicado: (2019)

Standardized benchmarking in the quest for orthologs
por: Altenhoff, Adrian M, et al.
Publicado: (2016)

Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2
por: Liu, Yinghui, et al.
Publicado: (2021)

Host range and structural analysis of bat‐origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs
por: Hu, Yu, et al.
Publicado: (2023)

Variations in cell-surface ACE2 levels alter direct binding of SARS-CoV-2 Spike protein and viral infectivity: Implications for measuring Spike protein interactions with animal ACE2 orthologs
por: Kazemi, Soheila, et al.
Publicado: (2021)

Variations in Cell Surface ACE2 Levels Alter Direct Binding of SARS-CoV-2 Spike Protein and Viral Infectivity: Implications for Measuring Spike Protein Interactions with Animal ACE2 Orthologs
por: Kazemi, Soheila, et al.
Publicado: (2022)

Influence of occlusal plane inclination and mandibular deviation on esthetics
por: Corte, Cristiane Cherobini Dalla, et al.
Publicado: (2015)

ExVe: The knowledge base of orthologous proteins identified in fungal extracellular vesicles
por: Parreira, Vinícius da Silva Coutinho, et al.
Publicado: (2021)

Hierarchical interactions between Fnr orthologs allows fine-tuning of transcription in response to oxygen in Herbaspirillum seropedicae
por: Batista, Marcelo Bueno, et al.
Publicado: (2018)

The Effect of Orthology and Coregulation on Detecting Regulatory Motifs
por: Storms, Valerie, et al.
Publicado: (2010)

The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2
por: Li, Pei, et al.
Publicado: (2021)

Human ACE2 orthologous peptide sequences show better binding affinity to SARS-CoV-2 RBD domain: Implications for drug design
por: Mahmoudi Azar, Lena, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_e8uf8qbi4vaogpodl3nn0oqfik