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The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting

Postoperative acute kidney injury (AKI) is a highly prevalent and serious complication after cardiac surgery. The aim of this study is to identify the predictors of AKI and the cut-off values after isolated off-pump coronary artery bypass grafting (OPCAB). A total of 329 adult patients, who underwen...

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Autores principales: Ishikawa, Masashi, Iwasaki, Masae, Namizato, Dai, Yamamoto, Makiko, Morita, Tomonori, Ishii, Yosuke, Sakamoto, Atsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475019/
https://www.ncbi.nlm.nih.gov/pubmed/36104386
http://dx.doi.org/10.1038/s41598-022-19772-7
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author Ishikawa, Masashi
Iwasaki, Masae
Namizato, Dai
Yamamoto, Makiko
Morita, Tomonori
Ishii, Yosuke
Sakamoto, Atsuhiro
author_facet Ishikawa, Masashi
Iwasaki, Masae
Namizato, Dai
Yamamoto, Makiko
Morita, Tomonori
Ishii, Yosuke
Sakamoto, Atsuhiro
author_sort Ishikawa, Masashi
collection PubMed
description Postoperative acute kidney injury (AKI) is a highly prevalent and serious complication after cardiac surgery. The aim of this study is to identify the predictors of AKI and the cut-off values after isolated off-pump coronary artery bypass grafting (OPCAB). A total of 329 adult patients, who underwent isolated OPCAB between December 2008 and February 2021, were retrospectively analyzed. The patients were divided into three groups: non-AKI, early AKI and late AKI groups. The early AKI group or the late AKI group were defined as ‘having AKI that occurred before or after 48 h postoperatively’, respectively. Multivariate logistic regression analysis was performed to identify the predictors of AKI. Receiver operating characteristic (ROC) curve analysis was used to evaluate the cutoff value, the sensitivity, and the specificity of the predictors. On the multivariate analysis, the emergency surgery, the preoperative serum albumin, and the postoperative day 1 neutrophil to lymphocyte ratio (NL ratio) were identified as the independent predictors of AKI. However, neither albumin nor the NL ratio predicted late AKI. The present study showed the preoperative albumin and the postoperative day 1 NL ratio were the robust and independent predictors of postoperative early AKI in isolated OPCAB.
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spelling pubmed-94750192022-09-16 The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting Ishikawa, Masashi Iwasaki, Masae Namizato, Dai Yamamoto, Makiko Morita, Tomonori Ishii, Yosuke Sakamoto, Atsuhiro Sci Rep Article Postoperative acute kidney injury (AKI) is a highly prevalent and serious complication after cardiac surgery. The aim of this study is to identify the predictors of AKI and the cut-off values after isolated off-pump coronary artery bypass grafting (OPCAB). A total of 329 adult patients, who underwent isolated OPCAB between December 2008 and February 2021, were retrospectively analyzed. The patients were divided into three groups: non-AKI, early AKI and late AKI groups. The early AKI group or the late AKI group were defined as ‘having AKI that occurred before or after 48 h postoperatively’, respectively. Multivariate logistic regression analysis was performed to identify the predictors of AKI. Receiver operating characteristic (ROC) curve analysis was used to evaluate the cutoff value, the sensitivity, and the specificity of the predictors. On the multivariate analysis, the emergency surgery, the preoperative serum albumin, and the postoperative day 1 neutrophil to lymphocyte ratio (NL ratio) were identified as the independent predictors of AKI. However, neither albumin nor the NL ratio predicted late AKI. The present study showed the preoperative albumin and the postoperative day 1 NL ratio were the robust and independent predictors of postoperative early AKI in isolated OPCAB. Nature Publishing Group UK 2022-09-14 /pmc/articles/PMC9475019/ /pubmed/36104386 http://dx.doi.org/10.1038/s41598-022-19772-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ishikawa, Masashi
Iwasaki, Masae
Namizato, Dai
Yamamoto, Makiko
Morita, Tomonori
Ishii, Yosuke
Sakamoto, Atsuhiro
The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
title The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
title_full The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
title_fullStr The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
title_full_unstemmed The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
title_short The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
title_sort neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475019/
https://www.ncbi.nlm.nih.gov/pubmed/36104386
http://dx.doi.org/10.1038/s41598-022-19772-7
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