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The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019

INTRODUCTION: South Sudan has made quite impressive progress in interrupting wild poliovirus and maintaining a polio-free status since the last case was reported in 2009. South Sudan introduced different complementary strategies to enhance acute flaccid paralysis (AFP) surveillance. Hence, the objec...

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Autores principales: Tegegne, Ayesheshem Ademe, Maleghemi, Sylvester, Anyuon, Atem Nathan, Zeleke, Fikiru Abebe, Legge, George Awzenio, Ferede, Melisachew Adane, Manyanga, Peter Daudi, Paul, Victor Guma, Mutebi, Nganda Moses, Ticha, Johnson Muluh, Kilo, Ochan Taban David, Ndenzako, Fabian, Pascal, Mkanda, Olu, Olushayo Oluseun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475052/
https://www.ncbi.nlm.nih.gov/pubmed/36158926
http://dx.doi.org/10.11604/pamj.supp.2022.42.1.33965
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author Tegegne, Ayesheshem Ademe
Maleghemi, Sylvester
Anyuon, Atem Nathan
Zeleke, Fikiru Abebe
Legge, George Awzenio
Ferede, Melisachew Adane
Manyanga, Peter Daudi
Paul, Victor Guma
Mutebi, Nganda Moses
Ticha, Johnson Muluh
Kilo, Ochan Taban David
Ndenzako, Fabian
Pascal, Mkanda
Olu, Olushayo Oluseun
author_facet Tegegne, Ayesheshem Ademe
Maleghemi, Sylvester
Anyuon, Atem Nathan
Zeleke, Fikiru Abebe
Legge, George Awzenio
Ferede, Melisachew Adane
Manyanga, Peter Daudi
Paul, Victor Guma
Mutebi, Nganda Moses
Ticha, Johnson Muluh
Kilo, Ochan Taban David
Ndenzako, Fabian
Pascal, Mkanda
Olu, Olushayo Oluseun
author_sort Tegegne, Ayesheshem Ademe
collection PubMed
description INTRODUCTION: South Sudan has made quite impressive progress in interrupting wild poliovirus and maintaining a polio-free status since the last case was reported in 2009. South Sudan introduced different complementary strategies to enhance acute flaccid paralysis (AFP) surveillance. Hence, the objective of this study is to evaluate the sensitivity of the surveillance system using the WHO recommended surveillance standard and highlight the progress and challenges over the years. METHODS: we conducted a retrospective, descriptive, quantitative study design and used the available secondary AFP surveillance database. RESULTS: the overall non-polio AFP rate was 6.2/100,000 children under 15 years old in the study period. The stool adequacy was maintained well above the certification level of surveillance. The two main surveillance performance indicators were met at the national level throughout the study period. In contrast, only five out of ten states persistently attained and maintained the two main surveillance performance indicators throughout the study period, while in 2019 all states achieved except for Jonglei state. During the analysis period, no wild poliovirus was isolated except two circulating Vaccine Derived Poliovirus Type 2 (cVDPV2) cases in 2014 and one Immunodeficiency Vaccine Derived Poliovirus Type 2 (iVDPV2) case in 2015. However, on average, three cases were classified as polio compatible with each year of the study. CONCLUSION: South Sudan met the two key surveillance performance indicators and had a sensitive AFP surveillance system during the period studied. We recommend intensifying surveillance activities in the former conflict-affected states and counties to maintain polio-free status.
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spelling pubmed-94750522022-09-23 The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019 Tegegne, Ayesheshem Ademe Maleghemi, Sylvester Anyuon, Atem Nathan Zeleke, Fikiru Abebe Legge, George Awzenio Ferede, Melisachew Adane Manyanga, Peter Daudi Paul, Victor Guma Mutebi, Nganda Moses Ticha, Johnson Muluh Kilo, Ochan Taban David Ndenzako, Fabian Pascal, Mkanda Olu, Olushayo Oluseun Pan Afr Med J Research INTRODUCTION: South Sudan has made quite impressive progress in interrupting wild poliovirus and maintaining a polio-free status since the last case was reported in 2009. South Sudan introduced different complementary strategies to enhance acute flaccid paralysis (AFP) surveillance. Hence, the objective of this study is to evaluate the sensitivity of the surveillance system using the WHO recommended surveillance standard and highlight the progress and challenges over the years. METHODS: we conducted a retrospective, descriptive, quantitative study design and used the available secondary AFP surveillance database. RESULTS: the overall non-polio AFP rate was 6.2/100,000 children under 15 years old in the study period. The stool adequacy was maintained well above the certification level of surveillance. The two main surveillance performance indicators were met at the national level throughout the study period. In contrast, only five out of ten states persistently attained and maintained the two main surveillance performance indicators throughout the study period, while in 2019 all states achieved except for Jonglei state. During the analysis period, no wild poliovirus was isolated except two circulating Vaccine Derived Poliovirus Type 2 (cVDPV2) cases in 2014 and one Immunodeficiency Vaccine Derived Poliovirus Type 2 (iVDPV2) case in 2015. However, on average, three cases were classified as polio compatible with each year of the study. CONCLUSION: South Sudan met the two key surveillance performance indicators and had a sensitive AFP surveillance system during the period studied. We recommend intensifying surveillance activities in the former conflict-affected states and counties to maintain polio-free status. The African Field Epidemiology Network 2022-06-11 /pmc/articles/PMC9475052/ /pubmed/36158926 http://dx.doi.org/10.11604/pamj.supp.2022.42.1.33965 Text en ©Ayesheshem Ademe Tegegne et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Tegegne, Ayesheshem Ademe
Maleghemi, Sylvester
Anyuon, Atem Nathan
Zeleke, Fikiru Abebe
Legge, George Awzenio
Ferede, Melisachew Adane
Manyanga, Peter Daudi
Paul, Victor Guma
Mutebi, Nganda Moses
Ticha, Johnson Muluh
Kilo, Ochan Taban David
Ndenzako, Fabian
Pascal, Mkanda
Olu, Olushayo Oluseun
The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019
title The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019
title_full The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019
title_fullStr The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019
title_full_unstemmed The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019
title_short The sensitivity of acute flaccid paralysis surveillance - the case of South Sudan: retrospective secondary analysis of AFP surveillance data 2014-2019
title_sort sensitivity of acute flaccid paralysis surveillance - the case of south sudan: retrospective secondary analysis of afp surveillance data 2014-2019
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475052/
https://www.ncbi.nlm.nih.gov/pubmed/36158926
http://dx.doi.org/10.11604/pamj.supp.2022.42.1.33965
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