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Biomarkers involved in the pathogenesis of cerebral small-vessel disease
Cerebral small-vessel disease (CSVD) has been found to have a strong association with vascular cognitive impairment (VCI) and functional loss in elderly patients. At present, the diagnosis of CSVD mainly relies on brain neuroimaging markers, but they cannot fully reflect the overall picture of the d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475115/ https://www.ncbi.nlm.nih.gov/pubmed/36119691 http://dx.doi.org/10.3389/fneur.2022.969185 |
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author | Liu, Xiaolu Sun, Pei Yang, Jing Fan, Yuhua |
author_facet | Liu, Xiaolu Sun, Pei Yang, Jing Fan, Yuhua |
author_sort | Liu, Xiaolu |
collection | PubMed |
description | Cerebral small-vessel disease (CSVD) has been found to have a strong association with vascular cognitive impairment (VCI) and functional loss in elderly patients. At present, the diagnosis of CSVD mainly relies on brain neuroimaging markers, but they cannot fully reflect the overall picture of the disease. Currently, some biomarkers were found to be related to CSVD, but the underlying mechanisms remain unclear. We aimed to systematically review and summarize studies on the progress of biomarkers related to the pathogenesis of CSVD, which is mainly the relationship between these indicators and neuroimaging markers of CSVD. Concerning the pathophysiological mechanism of CSVD, the biomarkers of CSVD have been described as several categories related to sporadic and genetic factors. Monitoring of biomarkers might contribute to the early diagnosis and progression prediction of CSVD, thus providing ideas for better diagnosis and treatment of CSVD. |
format | Online Article Text |
id | pubmed-9475115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94751152022-09-16 Biomarkers involved in the pathogenesis of cerebral small-vessel disease Liu, Xiaolu Sun, Pei Yang, Jing Fan, Yuhua Front Neurol Neurology Cerebral small-vessel disease (CSVD) has been found to have a strong association with vascular cognitive impairment (VCI) and functional loss in elderly patients. At present, the diagnosis of CSVD mainly relies on brain neuroimaging markers, but they cannot fully reflect the overall picture of the disease. Currently, some biomarkers were found to be related to CSVD, but the underlying mechanisms remain unclear. We aimed to systematically review and summarize studies on the progress of biomarkers related to the pathogenesis of CSVD, which is mainly the relationship between these indicators and neuroimaging markers of CSVD. Concerning the pathophysiological mechanism of CSVD, the biomarkers of CSVD have been described as several categories related to sporadic and genetic factors. Monitoring of biomarkers might contribute to the early diagnosis and progression prediction of CSVD, thus providing ideas for better diagnosis and treatment of CSVD. Frontiers Media S.A. 2022-09-01 /pmc/articles/PMC9475115/ /pubmed/36119691 http://dx.doi.org/10.3389/fneur.2022.969185 Text en Copyright © 2022 Liu, Sun, Yang and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Liu, Xiaolu Sun, Pei Yang, Jing Fan, Yuhua Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
title | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
title_full | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
title_fullStr | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
title_full_unstemmed | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
title_short | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
title_sort | biomarkers involved in the pathogenesis of cerebral small-vessel disease |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475115/ https://www.ncbi.nlm.nih.gov/pubmed/36119691 http://dx.doi.org/10.3389/fneur.2022.969185 |
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