Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites

An improved synthesis for tryptophan-dehydrobutyrine diketopiperazine (TDD), a co-metabolite of the hybrid polyketide/non-ribosomal peptide hangtaimycin, starting from ʟ-tryptophan is presented. Comparison to TDD isolated from the hangtaimycin producer Streptomyces spectabilis confirmed its S config...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Houchao, Wochele, Anne, Luo, Minghe, Schnakenburg, Gregor, Sun, Yuhui, Brötz-Oesterhelt, Heike, Dickschat, Jeroen S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475180/
https://www.ncbi.nlm.nih.gov/pubmed/36128431
http://dx.doi.org/10.3762/bjoc.18.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475180/
https://www.ncbi.nlm.nih.gov/pubmed/36128431
http://dx.doi.org/10.3762/bjoc.18.120

Ejemplares similares