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Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites

An improved synthesis for tryptophan-dehydrobutyrine diketopiperazine (TDD), a co-metabolite of the hybrid polyketide/non-ribosomal peptide hangtaimycin, starting from ʟ-tryptophan is presented. Comparison to TDD isolated from the hangtaimycin producer Streptomyces spectabilis confirmed its S config...

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Detalles Bibliográficos
Autores principales:	Xu, Houchao, Wochele, Anne, Luo, Minghe, Schnakenburg, Gregor, Sun, Yuhui, Brötz-Oesterhelt, Heike, Dickschat, Jeroen S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2022
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475180/ https://www.ncbi.nlm.nih.gov/pubmed/36128431 http://dx.doi.org/10.3762/bjoc.18.120

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