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Bioselectivity of silk protein-based materials and their bio-inspired applications

Adhesion to material surfaces is crucial for almost all organisms regarding subsequent biological responses. Mammalian cell attachment to a surrounding biological matrix is essential for maintaining their survival and function concerning tissue formation. Conversely, the adhesion and presence of mic...

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Autores principales: Bargel, Hendrik, Trossmann, Vanessa T, Sommer, Christoph, Scheibel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475208/
https://www.ncbi.nlm.nih.gov/pubmed/36127898
http://dx.doi.org/10.3762/bjnano.13.81
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author Bargel, Hendrik
Trossmann, Vanessa T
Sommer, Christoph
Scheibel, Thomas
author_facet Bargel, Hendrik
Trossmann, Vanessa T
Sommer, Christoph
Scheibel, Thomas
author_sort Bargel, Hendrik
collection PubMed
description Adhesion to material surfaces is crucial for almost all organisms regarding subsequent biological responses. Mammalian cell attachment to a surrounding biological matrix is essential for maintaining their survival and function concerning tissue formation. Conversely, the adhesion and presence of microbes interferes with important multicellular processes of tissue development. Therefore, tailoring bioselective, biologically active, and multifunctional materials for biomedical applications is a modern focus of biomaterial research. Engineering biomaterials that stimulate and interact with cell receptors to support binding and subsequent physiological responses of multicellular systems attracted much interest in the last years. Further to this, the increasing threat of multidrug resistance of pathogens against antibiotics to human health urgently requires new material concepts for preventing microbial infestation and biofilm formation. Thus, materials exhibiting microbial repellence or antimicrobial behaviour to reduce inflammation, while selectively enhancing regeneration in host tissues are of utmost interest. In this context, protein-based materials are interesting candidates due to their natural origin, biological activity, and structural properties. Silk materials, in particular those made of spider silk proteins and their recombinant counterparts, are characterized by extraordinary properties including excellent biocompatibility, slow biodegradation, low immunogenicity, and non-toxicity, making them ideally suited for tissue engineering and biomedical applications. Furthermore, recombinant production technologies allow for application-specific modification to develop adjustable, bioactive materials. The present review focusses on biological processes and surface interactions involved in the bioselective adhesion of mammalian cells and repellence of microbes on protein-based material surfaces. In addition, it highlights the importance of materials made of recombinant spider silk proteins, focussing on the progress regarding bioselectivity.
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spelling pubmed-94752082022-09-19 Bioselectivity of silk protein-based materials and their bio-inspired applications Bargel, Hendrik Trossmann, Vanessa T Sommer, Christoph Scheibel, Thomas Beilstein J Nanotechnol Review Adhesion to material surfaces is crucial for almost all organisms regarding subsequent biological responses. Mammalian cell attachment to a surrounding biological matrix is essential for maintaining their survival and function concerning tissue formation. Conversely, the adhesion and presence of microbes interferes with important multicellular processes of tissue development. Therefore, tailoring bioselective, biologically active, and multifunctional materials for biomedical applications is a modern focus of biomaterial research. Engineering biomaterials that stimulate and interact with cell receptors to support binding and subsequent physiological responses of multicellular systems attracted much interest in the last years. Further to this, the increasing threat of multidrug resistance of pathogens against antibiotics to human health urgently requires new material concepts for preventing microbial infestation and biofilm formation. Thus, materials exhibiting microbial repellence or antimicrobial behaviour to reduce inflammation, while selectively enhancing regeneration in host tissues are of utmost interest. In this context, protein-based materials are interesting candidates due to their natural origin, biological activity, and structural properties. Silk materials, in particular those made of spider silk proteins and their recombinant counterparts, are characterized by extraordinary properties including excellent biocompatibility, slow biodegradation, low immunogenicity, and non-toxicity, making them ideally suited for tissue engineering and biomedical applications. Furthermore, recombinant production technologies allow for application-specific modification to develop adjustable, bioactive materials. The present review focusses on biological processes and surface interactions involved in the bioselective adhesion of mammalian cells and repellence of microbes on protein-based material surfaces. In addition, it highlights the importance of materials made of recombinant spider silk proteins, focussing on the progress regarding bioselectivity. Beilstein-Institut 2022-09-08 /pmc/articles/PMC9475208/ /pubmed/36127898 http://dx.doi.org/10.3762/bjnano.13.81 Text en Copyright © 2022, Bargel et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjnano/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Review
Bargel, Hendrik
Trossmann, Vanessa T
Sommer, Christoph
Scheibel, Thomas
Bioselectivity of silk protein-based materials and their bio-inspired applications
title Bioselectivity of silk protein-based materials and their bio-inspired applications
title_full Bioselectivity of silk protein-based materials and their bio-inspired applications
title_fullStr Bioselectivity of silk protein-based materials and their bio-inspired applications
title_full_unstemmed Bioselectivity of silk protein-based materials and their bio-inspired applications
title_short Bioselectivity of silk protein-based materials and their bio-inspired applications
title_sort bioselectivity of silk protein-based materials and their bio-inspired applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475208/
https://www.ncbi.nlm.nih.gov/pubmed/36127898
http://dx.doi.org/10.3762/bjnano.13.81
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