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Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome

INTRODUCTION: Although breast milk is the ideal food source for newborns during the first six months of life, a high percentage of children receive infant formulas. There is evidence that specific diet habits may influence individual metabolic profile. Therefore, in newborns, such profile can be inf...

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Autores principales: Calvo Barbosa, Angie Marcela, Casallas Cortes, Stefany, Pulido, Ninna, Parra, Martha Yaneth, Rodríguez-López, Alexander, Guevara-Morales, Johana, Echeverri-Peña, Olga Yaneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475274/
https://www.ncbi.nlm.nih.gov/pubmed/36119867
http://dx.doi.org/10.1016/j.heliyon.2022.e10432
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author Calvo Barbosa, Angie Marcela
Casallas Cortes, Stefany
Pulido, Ninna
Parra, Martha Yaneth
Rodríguez-López, Alexander
Guevara-Morales, Johana
Echeverri-Peña, Olga Yaneth
author_facet Calvo Barbosa, Angie Marcela
Casallas Cortes, Stefany
Pulido, Ninna
Parra, Martha Yaneth
Rodríguez-López, Alexander
Guevara-Morales, Johana
Echeverri-Peña, Olga Yaneth
author_sort Calvo Barbosa, Angie Marcela
collection PubMed
description INTRODUCTION: Although breast milk is the ideal food source for newborns during the first six months of life, a high percentage of children receive infant formulas. There is evidence that specific diet habits may influence individual metabolic profile. Therefore, in newborns, such profile can be influenced by the use of infantile formulas given the composition differences that display compared to human milk. Up to now, there are no reports in the literature that address this issue. OBJECTIVES: this work aims to compare the metabolic profile of full-term newborns that were feed with either breast milk (n = 32) or infantile formulas (n = 21). Methods: Metabolic profile was established based on urine analysis through gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (H-NMR). RESULTS: our results evidenced a more gluconeogenic profile in breast-fed infants characterized by elevation of Kreb's cycle intermediaries like fumaric, succinic and ketoglutaric acids compared to infants receiving infant formula. In addition, infant formula fed infants presented urinary excretion of metabolites derived from specific compounds present in this type of diet that were not observed in breast-fed infants, for instance D-glucitol, and 4-deoxytetronic. Moreover, in infant formula fed infants there was excretion of basal levels of metabolites of clinical relevance like 3-hydroxy-3-methyl-glutaric, 2-methyl-3-keto-valeric and 3,4-dihydroxybutyric. CONCLUSION: These results show the importance of understanding the metabolic impact of diet in newborn population in normal and pathological contexts.
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spelling pubmed-94752742022-09-16 Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome Calvo Barbosa, Angie Marcela Casallas Cortes, Stefany Pulido, Ninna Parra, Martha Yaneth Rodríguez-López, Alexander Guevara-Morales, Johana Echeverri-Peña, Olga Yaneth Heliyon Research Article INTRODUCTION: Although breast milk is the ideal food source for newborns during the first six months of life, a high percentage of children receive infant formulas. There is evidence that specific diet habits may influence individual metabolic profile. Therefore, in newborns, such profile can be influenced by the use of infantile formulas given the composition differences that display compared to human milk. Up to now, there are no reports in the literature that address this issue. OBJECTIVES: this work aims to compare the metabolic profile of full-term newborns that were feed with either breast milk (n = 32) or infantile formulas (n = 21). Methods: Metabolic profile was established based on urine analysis through gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (H-NMR). RESULTS: our results evidenced a more gluconeogenic profile in breast-fed infants characterized by elevation of Kreb's cycle intermediaries like fumaric, succinic and ketoglutaric acids compared to infants receiving infant formula. In addition, infant formula fed infants presented urinary excretion of metabolites derived from specific compounds present in this type of diet that were not observed in breast-fed infants, for instance D-glucitol, and 4-deoxytetronic. Moreover, in infant formula fed infants there was excretion of basal levels of metabolites of clinical relevance like 3-hydroxy-3-methyl-glutaric, 2-methyl-3-keto-valeric and 3,4-dihydroxybutyric. CONCLUSION: These results show the importance of understanding the metabolic impact of diet in newborn population in normal and pathological contexts. Elsevier 2022-08-28 /pmc/articles/PMC9475274/ /pubmed/36119867 http://dx.doi.org/10.1016/j.heliyon.2022.e10432 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Calvo Barbosa, Angie Marcela
Casallas Cortes, Stefany
Pulido, Ninna
Parra, Martha Yaneth
Rodríguez-López, Alexander
Guevara-Morales, Johana
Echeverri-Peña, Olga Yaneth
Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome
title Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome
title_full Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome
title_fullStr Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome
title_full_unstemmed Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome
title_short Metabolic impact of infant formulas in young infants. An outlook from the urine metabolome
title_sort metabolic impact of infant formulas in young infants. an outlook from the urine metabolome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475274/
https://www.ncbi.nlm.nih.gov/pubmed/36119867
http://dx.doi.org/10.1016/j.heliyon.2022.e10432
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