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Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus

Apathy, a clinical disorder characterized by low motivation, is prevalent in people living with Human Immunodeficiency Virus (HIV). It affects mental and physical health-related quality-of-life, medication adherence, and is associated with cognitive decline. However, the causes of apathy and the und...

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Autores principales: Castaneda, Gloria, Fernandez Cruz, Ana-Lucia, Brouillette, Marie-Josée, Mayo, Nancy E., Fellows, Lesley K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475288/
https://www.ncbi.nlm.nih.gov/pubmed/36118691
http://dx.doi.org/10.3389/fnagi.2022.927209
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author Castaneda, Gloria
Fernandez Cruz, Ana-Lucia
Brouillette, Marie-Josée
Mayo, Nancy E.
Fellows, Lesley K.
author_facet Castaneda, Gloria
Fernandez Cruz, Ana-Lucia
Brouillette, Marie-Josée
Mayo, Nancy E.
Fellows, Lesley K.
author_sort Castaneda, Gloria
collection PubMed
description Apathy, a clinical disorder characterized by low motivation, is prevalent in people living with Human Immunodeficiency Virus (HIV). It affects mental and physical health-related quality-of-life, medication adherence, and is associated with cognitive decline. However, the causes of apathy and the underlying brain mechanisms in HIV are unknown. Brain responses to reward may be relevant to understanding apathy and might serve as biomarkers for diagnosis or treatment response. Electroencephalogram (EEG) responses to gain and loss feedback in simple guessing tasks have been related to apathy in neurodegenerative conditions and healthy individuals. The primary aim of this study is to contribute evidence regarding the relationship between two EEG correlates of reward processing, the Reward Positivity, and the Feedback-P300, and real-world motivated behavior indicated by self-reported hours engaged in goal-directed leisure activities per week, in older individuals with well-controlled HIV infection. High-density EEG was collected from 75 participants while they performed a guessing task with gain or loss feedback. We found that a later component of reward processing, the Feedback-P300, was related to real-world engagement, while the earlier Reward Positivity was not. The Feedback-P300 measured with EEG holds promise as a biomarker for motivated behavior in older people living with HIV. These findings lay the groundwork for a better understanding of the neurobiology of apathy in this condition.
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spelling pubmed-94752882022-09-16 Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus Castaneda, Gloria Fernandez Cruz, Ana-Lucia Brouillette, Marie-Josée Mayo, Nancy E. Fellows, Lesley K. Front Aging Neurosci Neuroscience Apathy, a clinical disorder characterized by low motivation, is prevalent in people living with Human Immunodeficiency Virus (HIV). It affects mental and physical health-related quality-of-life, medication adherence, and is associated with cognitive decline. However, the causes of apathy and the underlying brain mechanisms in HIV are unknown. Brain responses to reward may be relevant to understanding apathy and might serve as biomarkers for diagnosis or treatment response. Electroencephalogram (EEG) responses to gain and loss feedback in simple guessing tasks have been related to apathy in neurodegenerative conditions and healthy individuals. The primary aim of this study is to contribute evidence regarding the relationship between two EEG correlates of reward processing, the Reward Positivity, and the Feedback-P300, and real-world motivated behavior indicated by self-reported hours engaged in goal-directed leisure activities per week, in older individuals with well-controlled HIV infection. High-density EEG was collected from 75 participants while they performed a guessing task with gain or loss feedback. We found that a later component of reward processing, the Feedback-P300, was related to real-world engagement, while the earlier Reward Positivity was not. The Feedback-P300 measured with EEG holds promise as a biomarker for motivated behavior in older people living with HIV. These findings lay the groundwork for a better understanding of the neurobiology of apathy in this condition. Frontiers Media S.A. 2022-09-01 /pmc/articles/PMC9475288/ /pubmed/36118691 http://dx.doi.org/10.3389/fnagi.2022.927209 Text en Copyright © 2022 Castaneda, Fernandez Cruz, Brouillette, Mayo and Fellows. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Castaneda, Gloria
Fernandez Cruz, Ana-Lucia
Brouillette, Marie-Josée
Mayo, Nancy E.
Fellows, Lesley K.
Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus
title Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus
title_full Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus
title_fullStr Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus
title_full_unstemmed Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus
title_short Relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus
title_sort relationship between reward-related evoked potentials and real-world motivation in older people living with human immunodeficiency virus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475288/
https://www.ncbi.nlm.nih.gov/pubmed/36118691
http://dx.doi.org/10.3389/fnagi.2022.927209
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