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Regulation of Tumor and Metastasis Initiation by Chemokine Receptors

Tumor-initiating cells (TICs) are a rare sub-population of cells within the bulk of a tumor that are major contributors to tumor initiation, metastasis, and chemoresistance. TICs have a stem-cell-like phenotype that is dictated by the expression of master regulator transcription factors, including O...

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Autores principales: DiNatale, Anthony, Castelli, Maria Sofia, Nash, Bradley, Meucci, Olimpia, Fatatis, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475358/
https://www.ncbi.nlm.nih.gov/pubmed/36118530
http://dx.doi.org/10.7150/jca.72331
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author DiNatale, Anthony
Castelli, Maria Sofia
Nash, Bradley
Meucci, Olimpia
Fatatis, Alessandro
author_facet DiNatale, Anthony
Castelli, Maria Sofia
Nash, Bradley
Meucci, Olimpia
Fatatis, Alessandro
author_sort DiNatale, Anthony
collection PubMed
description Tumor-initiating cells (TICs) are a rare sub-population of cells within the bulk of a tumor that are major contributors to tumor initiation, metastasis, and chemoresistance. TICs have a stem-cell-like phenotype that is dictated by the expression of master regulator transcription factors, including OCT4, NANOG, and SOX2. These transcription factors are expressed via activation of multiple signaling pathways that drive cancer initiation and progression. Importantly, these same signaling pathways can be activated by select chemokine receptors. Chemokine receptors are increasingly being revealed as major drivers of the TIC phenotype, as their signaling can lead to activation of stemness-controlling transcription factors. Additionally, the cell surface expression of chemokine receptors provides a unique therapeutic target to disrupt signaling pathways that control the expression of master regulator transcription factors and the TIC phenotype. This review summarizes the master regulator transcription factors known to dictate the TIC phenotype, along with the complex signaling pathways that can mediate their expression and the chemokine receptors that are most upstream of this phenotype.
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spelling pubmed-94753582022-09-15 Regulation of Tumor and Metastasis Initiation by Chemokine Receptors DiNatale, Anthony Castelli, Maria Sofia Nash, Bradley Meucci, Olimpia Fatatis, Alessandro J Cancer Review Tumor-initiating cells (TICs) are a rare sub-population of cells within the bulk of a tumor that are major contributors to tumor initiation, metastasis, and chemoresistance. TICs have a stem-cell-like phenotype that is dictated by the expression of master regulator transcription factors, including OCT4, NANOG, and SOX2. These transcription factors are expressed via activation of multiple signaling pathways that drive cancer initiation and progression. Importantly, these same signaling pathways can be activated by select chemokine receptors. Chemokine receptors are increasingly being revealed as major drivers of the TIC phenotype, as their signaling can lead to activation of stemness-controlling transcription factors. Additionally, the cell surface expression of chemokine receptors provides a unique therapeutic target to disrupt signaling pathways that control the expression of master regulator transcription factors and the TIC phenotype. This review summarizes the master regulator transcription factors known to dictate the TIC phenotype, along with the complex signaling pathways that can mediate their expression and the chemokine receptors that are most upstream of this phenotype. Ivyspring International Publisher 2022-08-27 /pmc/articles/PMC9475358/ /pubmed/36118530 http://dx.doi.org/10.7150/jca.72331 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
DiNatale, Anthony
Castelli, Maria Sofia
Nash, Bradley
Meucci, Olimpia
Fatatis, Alessandro
Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
title Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
title_full Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
title_fullStr Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
title_full_unstemmed Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
title_short Regulation of Tumor and Metastasis Initiation by Chemokine Receptors
title_sort regulation of tumor and metastasis initiation by chemokine receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475358/
https://www.ncbi.nlm.nih.gov/pubmed/36118530
http://dx.doi.org/10.7150/jca.72331
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