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Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial

IMPORTANCE: Insufficient treatment response and resulting chronicity constitute a major problem in depressive disorders. Remission rates range as low as 15% to 40% and treatment-resistant depression (TRD) is associated with low-grade inflammation, suggesting anti-inflammatory interventions as a rati...

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Detalles Bibliográficos
Autores principales:	Hellmann-Regen, Julian, Clemens, Vera, Grözinger, Michael, Kornhuber, Johannes, Reif, Andreas, Prvulovic, David, Goya-Maldonado, Roberto, Wiltfang, Jens, Gruber, Oliver, Schüle, Cornelius, Padberg, Frank, Ising, Marcus, Uhr, Manfred, Friede, Tim, Huber, Cynthia, Manook, André, Baghai, Thomas C., Rupprecht, Rainer, Heuser, Isabella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2022
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475381/ https://www.ncbi.nlm.nih.gov/pubmed/36103181 http://dx.doi.org/10.1001/jamanetworkopen.2022.30367

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