Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System

IMPORTANCE: Serious mental illnesses, including schizophrenia, bipolar disorder, and depression, are heritable, highly multifactorial disorders and major causes of disability worldwide. OBJECTIVE: To benchmark the penetrance of current neuropsychiatric polygenic risk scores (PRSs) in the Veterans He...

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Detalles Bibliográficos
Autores principales: Bigdeli, Tim B., Voloudakis, Georgios, Barr, Peter B., Gorman, Bryan R., Genovese, Giulio, Peterson, Roseann E., Burstein, David E., Velicu, Vlad I., Li, Yuli, Gupta, Rishab, Mattheisen, Manuel, Tomasi, Simone, Rajeevan, Nallakkandi, Sayward, Frederick, Radhakrishnan, Krishnan, Natarajan, Sundar, Malhotra, Anil K., Shi, Yunling, Zhao, Hongyu, Kosten, Thomas R., Concato, John, O’Leary, Timothy J., Przygodzki, Ronald, Gleason, Theresa, Pyarajan, Saiju, Brophy, Mary, Huang, Grant D., Muralidhar, Sumitra, Gaziano, J. Michael, Aslan, Mihaela, Fanous, Ayman H., Harvey, Philip D., Roussos, Panos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475441/
https://www.ncbi.nlm.nih.gov/pubmed/36103194
http://dx.doi.org/10.1001/jamapsychiatry.2022.2742

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